PATHOPHYSIOLOGY OF GASTRIC ADENOCARCINOMA

Low acid secretion predisposes to gastric cancer by several

mechanisms, including impaired absorption of vitamin C and
overgrowth of salivary and intestinal bacteria within the
stomach. By contrast, proximal gastric cancer (at the gastro-
oesophageal junction) is associated with normal acid output.

Arises from the mucous lining of the Associated

stomach with presence
of H. pylori in
Hemorrhage or perforation the stomach
occurs

Presence of palpable mass, ascites, or bone pain

caused by metastasis

Stomach cancer spreads via

direct extension into the
pancreas via

lymphatics Infiltration Infiltration of the

of the liver lungs, and bones

Some tumors penetrate, ulcerate,

and spread along tissue planes

Invades the wall of the

stomach
Risk Factors:
• Individuals who live in urban areas
• Have low socio-economic status
• Eat smoked fish or meats
• Have a history exposure to background radiation or trace metals in soils
• Absorptions of carcinogens from the diet
• Tobacco smoke, nitrite food preservatives