CHOLERAEHOLERAE
Dr.T.V.Rao MDDr.T.V.Rao MD
Cholera affects MillionsCholera affects Millions
CHOLERA AFFECTS millions, in endemicCHOLERA AFFECTS millions, in endemicareas and causes thousands of deathsareas and causes thousands of deathsespecially during seasonal epidemics.especially during seasonal epidemics.Robert Koch, the famous microbiologist of Robert Koch, the famous microbiologist of Germany, discovered Vibrio cholerae, theGermany, discovered Vibrio cholerae, thecausative organism. Because of itscausative organism. Because of itscharacteristic shape he originally referredcharacteristic shape he originally referredto it as comma bacilli. Nearly 7-8to it as comma bacilli. Nearly 7-8epidemics caused by the pathogen `Vibrioepidemics caused by the pathogen `Vibriocholerae affected different parts of thecholerae affected different parts of theworld.world.
Discovery of CholeraDiscovery of CholeraOrganismsOrganisms
Cholera came to Florence in 1854 during theCholera came to Florence in 1854 during theAsiatic Cholera Pandemic of 1846-63Asiatic Cholera Pandemic of 1846-63. Pacini. Pacinibecame very interested in the disease.became very interested in the disease.Immediately following the death of choleraImmediately following the death of cholerapatients, he performed an autopsy and with hispatients, he performed an autopsy and with hismicroscope, conducted histological examinationsmicroscope, conducted histological examinationsof the intestinal mucosa. During such studies,of the intestinal mucosa. During such studies,Pacini first discovered a comma-shaped bacillusPacini first discovered a comma-shaped bacilluswhich he described as awhich he described as a
Vibrio.Vibrio.
He published aHe published apaper in 1854 entitled, "Microscopicalpaper in 1854 entitled, "Microscopicalobservations and pathological deductions onobservations and pathological deductions oncholera" in which he described the organism andcholera" in which he described the organism andits relation to the disease. His microscopic slidesits relation to the disease. His microscopic slidesof the organism were clearly labeled, identifyingof the organism were clearly labeled, identifyingthe date and nature of his investigations.the date and nature of his investigations.
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Cholerae
Cholera continues to be important communicable disease infects underprivileged living in third world countries improvement of hygiene continues to be basic tool in control of Cholera epidemics
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