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Alzforum Luc Letenneur

Alzforum Luc Letenneur

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Published by WorldEventsForum

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Published by: WorldEventsForum on Feb 25, 2011
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Seropositivity to Herpes Simplex Virus Antibodiesand Risk of Alzheimers Disease: A Population-BasedCohort Study
PLoS ONE 2008; 3(11): e3637.doi:10.1371/journal.pone.0003637
Luc LetenneurINSERM U 897, Bordeaux, FranceLuc.letenneur@inserm.fr
Epidemiological data
Renvoize (1987)
no statistically significant difference in serumantibody titres to HSV in a sample of 33 Alzheimersdisease (AD) patients and 28 controls.
Ounanian (1990)
in a sample of 19 AD patients and 21 controls, theproportion of HSV-positive subjects was not differentbetween AD and control groups but increased titresof anti HSV antibodies observed in the control group.
he PAQUID study
Longitudinal cohort of 3 777 subjects aged 65years and older, living at home in South-westFrance.
Subjects were followed for 14 years with regularcognitive evaluations.
Sub-sample of 512 subjects with blood sample.
Anti-HSV IgG and IgM antibodies assessment.

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