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Table Of Contents

Fundamental concepts
Introduction
BASIC CONCEPTS OF DESCRIPTIVE EPIDEMIOLOGY 3
Basic concepts of descriptive epidemiology
Time and the concept of incidence
Group characteristics and place
STATISTICAL CONCEPTS FOR THE ANALYSIS OF INCIDENCE DATA 11
Statistical concepts for the analysis of incidence data
Formal definition of the incidence rate
Estimation of the instantaneous incidence rate
An approximation useful in descriptive epidemiology
When individual observations are available and complete
When individual observations are available but possibly censored
STATISTICAL CONCEPTS IN SURVIVAL ANALYSIS 21
Statistical concepts in survival analysis
Follow-up studies
Survival probability
The life table
Classical models for survival distribution
Interactive risks
Competing risks
Relationship between incidence, mortality, survival and prevalence
Bi bliographical notes
REFERENCES
Techniques for the analysis of cancer risk
Measurement of the risk of cancer
Age- and sex-specific rates
The calculation of a specific rate
The accuracy of the estimate of a rate
The incidence curve
Standardized rates
Direct standardization
Cumulative rates
Indirect standardization
Probability of developing a specific form of cancer
Methods for comparison
Comparison of incidence of a disease in two groups
The approximate method
Mantel-Haenszel test
Overall measure of incidence ratio
Test of a multiplicative model
Trend test
Comparison of incidence among several populations
Comparison with an overall expected value
Homogeneity test for incidence
Use of the log-linear model
EXTENSION AND LIMITATIONS OF THE PRESENT METHODOLOGY 95
Extension and limitations of the present methodology
Risk analyses in the absence of denominators
Standardized indices of relative frequency
Modelling incidence data in the absence of the denominator
Choosing between various risk measures
Bibliographical notes
Geographical analysis
The objectives of cartography
Choice of a risk indicator
Definition of risk classes
Tools to interpret geographical data
A utocorrelations
Identifying risk clusters
Time-space clustering
Smoothing and the empirical Bayes method
Concluding remark
ECOLOGICAL STUDIES 141
Ecological studies
Aim and methodological principles
Strengths and limitations of a measure of group exposure
Group versus individual exposure
Risk estimation in the context of an ecological study
The ecological fallacy
Definition of groups
Multivariate analysis
Migrant studies
Time trends
Objectives
Methods
Components of temporal evolution
Effect of data quality
Description of trend by period
Description of trend by cohort
Age-period-cohort models
Specific techniques and examples
Epidemiological evaluation of a secondary prevention campaign
Trends in cancer of the uterine cervix
METHODS OF COMPARISON 245
Methods of comparison
Comparison of crude survival probabilities
Test to compare two survival rates
Rank tests to compare survival curves
Stratified comparison of crude survival
Principle of the Cox model estimation
The likelihood ratio tesf
Example of an adjustment using Cox's model
Comparison of net survival
Bi bliographical Notes
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Cancer StatisticalMethods Book

Cancer StatisticalMethods Book

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Published by Nikolas Macnick

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Published by: Nikolas Macnick on Mar 19, 2011
Copyright:Attribution Non-commercial

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10/25/2012

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