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Medical Biochemistry

Medical Biochemistry

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The Medical Biochemistry
The Medical Biochemistry

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Published by: Sheryl Vistal Saboriendo on Mar 19, 2011
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SIU School of Medicine BIOCHEMISTRY
 
pH and Structural BiologyFaculty: J.W. Shriver Problem Unit 1 - Page 1
MEDICAL BIOCHEMISTRYProblem Unit One1999/2000pH and Structural Biology
Module 1: Acid/Base Properties of BiomoleculesModule 2: Amino Acids, Peptides, and ProteinsModule 3: Structural Biology and Disease
 
SIU School of Medicine BIOCHEMISTRY
 
pH and Structural BiologyFaculty: J.W. Shriver Problem Unit 1 - Page 2
Faculty: Dr. John W. ShriverDepartment of Biochemistry and Molecular BiologyOffice: 289 Neckers Bldg.email: jshriver@som.siu.eduTelephone: 453-6479
LEARNINGRESOURCES:
ESTIMATED WORK TIME: 40 hours.A. This study guide is provided in two forms: printed and electronic.
I strongly encourage you to obtain the electronic form as a pdf fileand install it on your computer so that it can be read using AdobeAcrobat Reader.
See Appendix II for an introduction on how toview a pdf file. The pdf file can be downloaded from the biochemis-try server (
) and AcrobatReader canbe downloaded without charge from Adobe’s web page(
 
). They should also be installed onthe student computers. There are a number of advantages to usingthe electronic version including color, a hypertext index, and hyper-text links within the text. Hypertext links in the text body are in blueunderlined characters (
.Clicking on these will lead to ajump to the linked material for further details. The destination mate-rial is highighted with red underlined characters (
such as this) tomake it easy for you to find on the page
. The red underlined text isnot a hyperlink - only a destination.This and other study guides are provided to help you focus on thetopics that are important in the biochemistry curriculum. These aredesigned to guide your studying and provide information that maynot be readily available in other resources. They are not designed toreplace textbooks, and are not intended to be complete. They areguides for starting your reading. The pdf electronic versions shouldbe especially useful for quick reviews at a later date. The hypertextNomenclature and Vocabulary sections should permit rapid scanningof the key points.B.Textbooks:1.Devlin, Textbook of Biochemistry with Clinical Correla-tions, Thomas. Core text for Medical Biochemistry.2.Champ & Harvey, Lippincotts Illustrated Reviews of Bio-chemistry, current ed., Lippincotts. Efficient presentation of basic principles.3.Murray et al., Harper's Biochemistry, (23rd ed.) ('93), Pren-tice-Hall, Inc. An excellent review text for examinations.
 
SIU School of Medicine BIOCHEMISTRY
 
pH and Structural BiologyFaculty: J.W. Shriver Problem Unit 1 - Page 3
Most textbooks of biochemistry contain sections on pH and dissocia-tion and protein structure; some are more extensive than others. Anybiochemistry textbook that covers the subject in sufficient detail soyou can answer the questions in the Problem Sets and Practice Examshould be sufficient. Additional material can be found on the web atthe National Institutes of Health(
 
 
), theNational Library of Medicine(
 
 
), and thefree MEDLINE PubMED Search system at the NationalLibrary of Medicine (
 
 
).C.Lecture/DiscussionsEspecially recommended for those who have not had biochemistryand for those who have questions.
EVALUATIONCRITERIA:
 A written examination will be scheduled. Answers to questions andthe solving of problems will be judged against the learning resources.Examples of exam questions are given in the Problem Sets. The passlevel is 70%.
 Module 1: Acid/Base Chemistryof Biomolecules
 INTRODUCTION:
 Water makes up about 70% of a typical cell by weight. It is one of two solvents in which most of biochemistry occurs, the second beingthe lipids of membranes. Water is a very unusual substance and playsa central role in defining life as we know it. Its large dipole momentmeans that it is a highly
polar
liquid (at 37°C) and thus serves as anexcellent solvent for other polar (and
hydrophilic
 
 
) molecules.
Apo-lar
 molecules are not easily dissolved in water and are referred to as
 hydrophobic.
Hydrophobic molecules are excluded from an aque-ous environment because they cannot interact well with water andtherefore lead to a structuring of water in their vicinity (an unfavor-able process). Since hydrophobes generally mix well, they separate tominimize their interface with water and form a second distinct envi-ronment - the greasy, oily environment of lipids (
 lipophilic
 
 
). Thebiochemical system can be viewed as two different environments: the

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