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is localized in one of the lower limbs; is a strap of linear hardenedhyperpigmented tegument In children, the sclerodermic process may arrest even thegrowth of the bone in the affected limbIn the generalized forms, scleroderma starts by an inflammatory process, followed bythe induration of the tegumentary tissue on the limbs, trunk and face. Tissue fibrosis alsoaffects the esophagus, the intestines, the lungs, the heart and the kidneys. The pathologicalalterations of the cardio-vascular system pose the risk of hypertension and cerebral vascularaccident. The patients with generalized or systemic scleroderma show the symptoms of the CREST syndrome:
rheumatic symptoms: arthritis;
esophageal disorders: disorders in the muscle functions, and disorders of theesophageal tube, burning in the esophagus and in the chest;
congestive cardiac insuficiency;
Raynaud syndrome symptoms: spasms in the capillaries that vascularise the fingersand the toes, the nose, the tongue and the ears; the areas inadequately vascularizedchange their color into blue, white and then into red when they are exposed to verylow or very high temperatures, or when the patient undergoes very powerful emotions.
Causes and treatment
The pathological process of collagen proliferation is caused by a dysfunction in theproduction of this protein. The production of collagen is done with the participation of thethesaurus organs, except the heart, namely the liver, the lungs, the pancreas, the spleen andthe kidneys. The disorders in collagen production occur when the areas carrying out thesefunctions in the respective organs become non functional or work at low capacity, as a resultof a poor innervation and of a vascularisation too rich but with a low oxygen supply.