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MEKANISME

HEMOSTASIS

SUB BAG. HEMATO-ONKOLOGI


ANAK FK USU
1
ADA 5 KOMPONEN:

1. KOMP.JARINGAN:
- JAR.LONGGAR  PERDARAHAN
BANYAK
2. KOMP.PEMBULUH DARAH:
- VASOKONSTRIKSI
- FAKTOR PENARIK TROMBOSIT
3. KOMP.TROMBOSIT: 2
- MENJAGA INTEGRITAS
PEMB.DARAH
- MEMBENTUK GUMPALAN
- CLUMPING
4. KOMP.PEMBEKUAN:
- MENGUBAH GUMPALAN
TROMBOSITMASSA YG KOMPAK
- MENGHASILKAN BEKUAN DI DLM
PEMB.DARAH BESAR
- REAKSI KASKADE
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5. KOMP.FIBRINOLISIS
- TERDAPAT FAKTOR-FAKTOR
INAKTIF, AKTIF, AKTIFATOR &
INHIBITOR
- DIAKTIFKAN OLEH LATIHAN
BERAT, ANOKSIA, KETEGANGAN
(STRESS) DAN SUNTIKAN
ADRENALIN
NORMAL HAEMOSTASIS 4
VESSEL INJURY
TISSUE
COLLAGEN EXPOSURE TROMBOPLASTIN
F. XII
PLATELET RELEASE
REACTION
SEROTONIN PLATELET
FACTORS
BLOOD
VACOKONSTRICTION TROMBOXANE A2, ADP COAGULATION
REDUCED PLATELET AGGREGATION
BLOOD FLOW THROMBIN
PRIMARY HAEMOSTATIC PLUG

PLATELET FUSION

STABLE HEMOSTATIC PLUG FIBRIN


TF • VII
CONTACT
5
VESSEL
INJURY IX

TF • VII a XIa XI

TFPI

F
vW
VIIIa • IX a

1•
V

1
V1
Xa • Va THROMBIN
FIBRINOGEN FIBRIN MONOMER

PROTHOMBRIN FIBRIN
FIBRINOPEPTIDES
POLYMER
A+B
XIII XIIIa

PHOSPHOLIPID STABLE FIBRIN


SURFACE
6
COAGULATION FACTOR
DEFICIENCIES
1. COMMON INHERITED DEFICIENCIES
- F. VIII ( CLASSICAL HEMOPHILIA;
HEMOPHILIA A )
- vWF ( VON WILLEBRAND DISEASE )
- F.IX ( CHRISTMAS DISEASE;
HEMOPHILIA B )
- F. XI
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2. UNCOMMON INHERITED DEFICIENCIES
- FIBRINOGEN & DYSFIBRINOGEN
- PROTHROMBRIN (F.II) &
DYSPROTHOMBRIN
- F. V ( PARAHEMOPHILIA )
- F. VII
- F. X
- F.XII
- F.XIII
- COMBINED DEFICIENCIES
- OTHER
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3. ACQUIRED DEFICIENCIES
- VIT. K
- CONSUMPTION COAGULOPATHY
- PARENCHYMAL LIVER DISEASE
- CONGENITAL HEART DISEASE
- CARDIOPULMONARY BYPASS
- RENAL DISEASE
- ACQUIRED INHIBITORS
( CIRCULATING ANTICOAGULANTS )
- OTHER
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4. NEONATAL DEFICIENCIES
- HEMORRHAGIC DISEASE OF THE
NEWBORN
- INHERITED DEFICIENCIES
- ACQUIRED DEFICIENCIES
PENILAIAN KLINIK: 10
LARGE ECCHYMOSIS
HEMATOMA
HEMARTHROSIS

PTT-PROLONGED PTT-NORMAL PTT-PROLONGED PTT-NORMAL


PT-NORMAL PT-PROLONGED PT-NORMAL
PT- PROLONGED

F.VII DEF. TT-PROLONGED TT-NORMAL


HEMOPHILIAS
vWD F.XII DEF.
CIRCULATING 2 NTIPLASMIN
LIVER DIS.
ANTICOAGULANT
AFIBRINOGENEMIA VIT.K DEF. DEF.
HEPARIN
DYSFIBRINOGENEMIA WARFARIN
DIC F.II,V,X DEF.
LIVER DISEASE HEPARIN DIC (EARLY)
CIRCULATING
ANTICOAGULANT
DYSPROTHOMBINEMIA

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