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Table Of Contents

1. TEACHING PROGRAMME
2. MINIMUM ESSENTIAL SYLLABUS FOR RADIOBIOLOGY
2.1. Introduction
2.2. Physics and chemistry of radiation interactions with matter
2.2.1. Sources of ionizing radiation
2.2.2. Types of ionizing radiation
2.2.3. Particulate radiations
2.2.4. Linear energy transfer
2.2.5. Radiation dose and units
2.2.6. Principles of radiation dosimetry
2.2.7. Direct and indirect effects
2.3. Molecular and cellular radiobiology
2.3.1. Radiation lesions in DNA
2.3.2. Major types of DNA repair
2.3.3. Damage recognition and signalling
2.3.4. Consequences of unrepaired DNA damage: Chromosome damage
2.3.6. Suvival curves and models
2.3.7. Cell cycle effects
2.3.9. Cellular repair exemplified in survival curves
2.3.10. Cellular hyper-radiosensitivity (HRS) and induced repair (IRR)
2.3.11. Other molecular targets: bystander (epigenetic) effects
2.3.12. Radiation sensitisers
2.3.13. Radiation protectors
2.4. Tumour radiotherapy
2.4.1. Tumour growth
2.4.2. Tumour response to irradiation
2.4.3. Dependence of tumour control on dose and tumour size
2.4.4. Dose fractionation effects
2.4.5. Predicting the radiation response of tumours
2.4.6. Tumour hypoxia
2.5. Normal tissue response to radiotherapy
2.5.1. Cellular and tissue response
2.5.2. Acute tissue responses
2.5.3. Late tissue responses
2.5.4. Predicting normal tissue response
2.5.5. Therapeutic ratio
2.5.6. Whole body irradiation
2.6. Radiobiological basis of radiation protection
2.6.2. Long term radiation risks from low radiation doses
2.6.3. Radiation-induced cancer in the A-bomb survivors
2.6.4. Epidemiological studies in other radiation-exposed populations
2.6.7. Radiation-induced heritable diseases
REFERENCES TO SECTION 2
3. EXTRA MODULE FOR RADIATION ONCOLOGISTS
3.1. Introduction
3.2. Physics
3.2.1. Brachytherapy, radionuclides, and radioimmunotherapy
3.2.2. Charged particles and high LET radiotherapy
3.2.3. Boron neutron capture therapy (BNCT)
3.3. Molecular and cellular biology
3.3.1. Techniques
3.3.2. Cell signaling
3.3.3. Oncogenes and tumour suppressor genes
3.4. The cell cycle
3.4.1. Cycle-dependent kinases and cyclins
3.4.2. Activation of Cdks by binding to cyclins
3.4.3. Inhibitors of cyclin-dependent kinases
3.5. DNA damage and repair
3.6. Tumour growth and cell kinetics
3.6.1. Tumour growth
3.6.2. Cell kinetics
3.6.3. Cell proliferation in normal tissues
3.7. Cell death mechanisms
3.8. In vitro and in vivo assays for cell survival
3.9. Repair of radiation damage
3.10. Tumour biology and host/tumour interactions
3.11. Radiobiology of normal tissue damage
3.11.2. Late tissue responses
3.11.3. Whole body irradiation
3.11.4. Retreatment tolerance
3.11.5. Volume effects
3.11.6. Therapeutic ratio (or index)
3.12. Time-dose-fractionation
3.12.1. Repair
3.12.2. Repopulation
3.12.3. Redistribution/recruitment
3.12.4. Reoxygenation
3.12.5. Time and dose relationships
3.12.6. Isoeffect curves
3.12.7. The linear quadratic equation and models for isoeffect
3.12.8. Altered fractionation schedules
3.13. Predictive assays
3.13.1. Predicting the response of tumours
3.13.2. Predicting normal tissue response
3.14. Combined radiation and drug treatments
3.15. Clinical radiobiology of common cancers
3.16. Second cancers in radiotherapy patients
3.17. Summary
REFERENCES TO SECTION 3
4. EXTRA MODULE FOR RADIATION PROTECTION PERSONNEL
4.1. Introduction
4.2. Radiation accidents and environmental radiation exposure
4.2.1. Dose estimation
4.3. Diagnosis and medical management of radiation syndromes
4.3.1. LD-50 (Lethal dose 50)
4.3.2. Radiation syndromes
4.3.3. Medical management of radiation accidents
4.3.4. Methods of triage for treatment after a radiation accident
4.4. Radiation carcinogenesis
4.4.1. Mechanisms of carcinogenesis
4.4.2. Epidemiological evidence for radiation carcinogenesis
4.4.4. The Chernobyl accident
4.4.5. Patients treated for benign diseases
4.4.6. Radon exposure of hard rock miners or in homes
4.5. Heritable radiation effects
4.6. Effects on the developing embryo
4.7. The system for radiation protection
4.7.2. Dose limits
REFERENCES TO SECTION 4
LIST OF CONTRIBUTORS TO DRAFTING AND REVIEW
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radiobiologie

radiobiologie

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Published by: pest19 on Apr 04, 2011
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