• Found in hair, fingernails, claws, horns andbeaks• Sequence consists of 311-314 residuealpha helical rod segments capped withnon-helical N- and C-termini• Primary structure of helical rods consistsof 7-residue repeats: (a-b-c-d-e-f-g)
,where a and d are nonpolar. Promotesassociation of helices!
Both type I and type II
-keratin molecules have sequences consisting of long,central rod domains with terminal cap domains. The numbers of amino acid residues ineach domain are indicated. Asterisks denote domains of variable length.
The roddomains form coiled coils consisting of intertwined right-handed
-helices. These coiledcoils then wind around each other in a left-handed twist. Keratin filaments consist oftwisted protofibrils (each a bundle of four coiled coils).
Adapted from Steinert, P., and Parry,D., 1985
. Annual Review of Cell Biology
and Cohlberg, J., 1993.
Trends in BiochemicalSciences