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Hope in the Pipeline II: Pharmaceuticals (Ann Ginsberg, M.D., Ph.D.)

Hope in the Pipeline II: Pharmaceuticals (Ann Ginsberg, M.D., Ph.D.)

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Published by: National Press Foundation on Apr 08, 2011
Copyright:Attribution Non-commercial

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02/11/2014

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The TB Drugs Pipeline:
From Drugs to Regimens (CPTR and NC-001)
Dr. Ann Ginsberg Chief Medical Officer, TB AllianceNovember 12, 2010 Berlin, Germany 
 
The Threat of TB
TB remains one of the world’s deadliest infectiousdiseases – second only to HIV/AIDS – killing one personevery 20 secondsEach year, TB kills more than 1.8 million people, andthere are 9.4 million new cases, primarily in developingcountriesTB’s complex and deadly interaction with HIV/AIDS haseven further exacerbated the global TB epidemicThere is an urgent unmet need for better treatments.
 
Current TB Therapy and Unmet Needs
Patient Population CurrentTherapyUnmetNeeds
Drug-Susceptible TB 4 drugs; ≥6 month therapy Shorter, simpler therapyDrug-ResistantM(X)DR-TBFew drugs (including injectables);≥18 months therapy; toxicitiesTotally oral, shorter, moreefficacious, safer and lower cost therapyTB/HIVCo-InfectionDrug-drug interactions with HIVmedicationsAbility to easily co-administer TB regimens with ARVsLatent TBInfection6-9 months of treatment Shorter, safer therapy
All treatments for active TB must be multidrug regimensSignificant improvements in therapy are needed for all patient populations

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