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Microbicides (Ian McGowan, M.D., Ph.D. FRCP)

Microbicides (Ian McGowan, M.D., Ph.D. FRCP)

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Published by: National Press Foundation on Apr 08, 2011
Copyright:Attribution Non-commercial

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11/14/2013

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All You Need to KnowAbout Microbicides
Ian McGowan MD PhD FRCPCo-PI Microbicides Trial Network (MTN)Center for Prevention ResearchDavid Geffen School of Medicine at UCLA
Why Do We Need Microbicides?Global Prevalence of HIV/AIDSOverview
What is a microbicide?How do microbicides work?Who is developing microbicides?What products are being developed?How close to a product are we?What are rectal microbicides?Why has the development of someproducts been stopped prematurely?What news is on the horizon?
Biomedical Prevention
AbstinenceCondomsBehavioral modificationDiagnosis and treatment of STIsHSV suppressionPREP/PEPCircumcisionVaccinesMicrobicides
 
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What is a Microbicide?
A microbicide is a product that canbe applied to the vaginal or rectalmucosa with the intention ofpreventing or significantly reducingthe transmission of sexuallytransmitted infections including HIVinfection
 
What Might Microbicides LookLike?How do Microbicides Work?How Does the Virus Get In?
McGowan I, Biologicals, 2006McGowan I, Biologicals, 2006
How Do Microbicides PreventInfection?
 
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Where Do Products Go?
Charles Lacey MD, & Craig Hendrix MD
Who is DevelopingMicrobicides?Microbicide Manufacturers
Gilead Sciences Inc.• StarPharma Holdings LtdIndevus Pharmaceuticals Inc.• Reprotect LLC• Tibotec Pharmaceuticals Ltd
The Microbicide Trials Network
NIH funded networkPI: Dr. Sharon HillierFounded in 2006Based in PittsburghDomestic andInternational sitesConducting Phase 1, 2and 2B microbicidestudies
http://www.mtnstopshiv.org/ 
MTN Clinical Trials
225Registry
MTN-015Year
2002
MTN-007
40002B
MTN-003
401
MTN-002
602
MTN-001
2002
HPTN-059
32202/2B
HPTN-0351312111009080706NPhaseStudy
Ongoing StudiesPlanned Studies
CONRAD
Established in 1986Executive Director:Henry GabelnickStrategic focus:
Contraception– Prevention of sexualtransmission ofHIV/AIDS and otherinfections.
http://www.conrad.org/ 
Product Portfolio
Cellulose sulfateTenofovirUC-781

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