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Table Of Contents

Chapter 1: History
1.1. Primeval tuberculosis
1.2. Phthisis/consumption
1.3. The White Plague
1.4. The discovery of the tubercle bacillus
1.5. Sanatorium and initial therapies
1.7. A global health emergency
2.1. A basic evolutionary scheme of mycobacteria
2.2. M. tuberculosis complex population molecular genetics
2.3. Co-evolution of M. tuberculosis with its hosts
2.4. M. tuberculosis through space and time
2.5. Looking for robust evolutionary markers
2.6. Why repeated sequences were so useful at the beginning
2.7. Regions of differences (RDs) and SNPs in M. tuberculosis
2.8. Looking for congruence between polymorphic markers
2.9. Main lineages within the M. tuberculosis species
2.10. When did the bovine-human switch of M. tuberculosis take place?
2.11. Comparative genomics and evolution of tubercle bacilli
2.12. Short-term evolutionary markers and database building
2.13. Conclusion and Perspectives
Chapter 3: The Basics of Clinical Bacteriology
3.1. The tubercle bacillus: a continuous taxon
3.2. Microscopic morphology
3.3. Cell wall structure
3.4. Nutritional and environmental requirements for growth
3.5. Generation time
3.6. Metabolic and biochemical markers
3.7. Resistance to physical and chemical challenges
Chapter 4: Genomics and Proteomics
4.2. M. tuberculosis genome
4.3. Gene expression in M. tuberculosis
4.4. M. tuberculosis proteome
4.5. An insight into M. tuberculosis metabolomics
4.6. Concluding remarks
Chapter 5: Immunology, Pathogenesis, Virulence
5.1. Immune response against Mycobacterium tuberculosis
5.3. Latency and maintenance of the immune response
5.4. Immunotherapy for tuberculosis
5.5. Concluding remarks
Chapter 6: Host Genetics and Susceptibility
6.2 Search for mutations and polymorphisms that increase susceptibility
6.3. Candidate genes in common tuberculosis
6.4 Genes from mouse genetic susceptibility studies
6.5. The good, the bad and the maybe, in perspective
Chapter 7: Global Burden of Tuberculosis
7.1. Global epidemiology of tuberculosis
7.2. Tuberculosis and the interaction with the HIV epidemic
7.3. Progress of the DOTS strategy
7.4. The new Stop TB strategy
8.1. Mycobacterium bovis disease in humans
8.2. The BCG vaccine: adverse reactions
8.3. Mycobacterium africanum subtypes
8.4. Mycobacterium microti disease
8.5. Mycobacterium caprae and Mycobacterium pinnipedii
8.6. Identification of species within the M. tuberculosis complex
9.1. Introduction
9.2. Historical context
9.3. Infectiousness of tuberculosis patients
9.4. DNA fingerprinting, contact investigation and source case finding
9.5. Transmission of drug resistant tuberculosis
9.6. Resistance and the Beijing genotype
9.7. Genetic heterogeneity of M. tuberculosis and multiple in- fections
9.8. The new standard genetic marker: VNTR typing
9.9. DNA fingerprinting to monitor eradication of tuberculosis
9.10. Future prospects
Chapter 10: New Vaccines against Tuberculosis
10.1. Introduction
10.2. Historical view
10.3. Genetic diversity between BCG vaccines
10.4. New vaccines: from the bench to clinical trials
10.5. Subunit vaccine candidates
10.6. Subunit vaccines for boosting BCG
10.7. Recombinant BCG vaccines
10.8. Live vaccines based on attenuated M. tuberculosis
10.9. Conclusions
Chapter 11: Biosafety and Hospital Control
11.1. Biosafety in the hospital
11.2. Biosafety in the laboratory
Chapter 12: Conventional Diagnostic Methods
12.1. Introduction
12.2. Specimen handling
12.3. Smear staining
12.4. Adenosine deaminase activity
12.5. Culture
12.6. Identification
Chapter 13: Immunological Diagnosis
13.1. Historical Overview
13.2. Current methods of tuberculosis diagnosis
13.3. Basis of immunological diagnosis
13.4. Serological assays
13.5. T cell based assays
13.6. Conclusions and Perspectives
Chapter 14: New Diagnostic Methods
14.1. Introduction
14.2. Automated culture methods
14.3. Nucleic acid amplification methods
14.4. Genetic identification methods
14.5. Non-conventional phenotypic diagnostic methods
15.5. Tuberculosis disease
15.6. Diagnostic approaches
15.7. Treatment of latent tuberculosis infection
15.8. Contact tracing and control
15.9. The limits between infection and disease
Chapter 16: Tuberculosis in Children
16.1. Introduction
16.2. Etiology, transmission and pathogenesis
16.3. Primary pulmonary tuberculosis
16.4. Non-respiratory disease
16.5. Congenital tuberculosis
16.6. Diagnosis
16.7. Pediatric tuberculosis treatment
16.8. Vaccination
16.9. Prognosis of pediatric tuberculosis
Chapter 17: Tuberculosis and HIV/AIDS
17.1. Epidemiological background
17.2. Interactions between M. tuberculosis and HIV infection
17.3. Clinical characteristics
17.4. Multidrug-resistant tuberculosis and HIV/AIDS
17.5. Treatment of tuberculosis in HIV/AIDS patients
17.6. Immune reconstitution inflammatory syndrome
17.7. Treatment of latent tuberculosis infection in HIV/AIDS patients
17.8. Mycobacteriosis in AIDS patients
Chapter 18: Drugs and Drug Interactions
18.1. Introduction
18.2. Overview of existing treatment schemes
18.3. Drugs: structure, pharmacokinetics and toxicity
18.5. Drug interactions
18.6. New drugs for tuberculosis
18.7. Useful links
Chapter 19: Drug Resistance and Drug Resistance Detection
19.1. Introduction
19.2. Drug resistance surveillance
19.3. Methods for detection of drug resistance
Chapter 20: New Developments and Perspectives
20.1. The scenario
20.2. Bacillus and disease under the light of molecular epide- miology
20.3. New perspectives in diagnosis
20.4. The problem of drug resistance detection
20.5. On drug development
20.6. On vaccine development
20.7. Global management of research & development re- sources
20.8. Useful links
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tuberculosis 2007

tuberculosis 2007

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Published by Chhay Vanna

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Published by: Chhay Vanna on Apr 12, 2011
Copyright:Attribution Non-commercial


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