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GRANULOCYTES AGRANULOCYTES
NEUTROPHILS
NOMAD:2006: BP: Leucocytes I 4
50 -70
NEUTROPHILS
Most numerous Leucocytes ( 50 –
70%)
Are 10 – 14 Microns in diameter.
Have a constantly changing
shape due to amoeboid
movements.
The Nucleus can have 1 – 7 lobes
connected by a fine strand.
The Cytoplasm contains 50 – 200
fine granules.
NOMAD:2006: BP: Leucocytes I 5
NOMAD:2006: BP: Leucocytes I 6
NEUTROPHILIA
NEUTROPHILIA: Increased
neutrophil count, can be due to:
Release of stored cells from the
bone marrow reserves.
Bacterial Infections causing
increased Neutropoiesis.
Exercise can cause release of
stored neutrophils.
Phosphatases.
Nucleases.
Lymphocytes:
Sized about 12 –
15 µ
Thin cytoplasmic
rim
Large spherical
nucleus
No cytoplasmic
( Smallest
Leucocytes)
Thin cytoplasmic
visible.
NOMAD:2006: BP: Leucocytes I 17
NOMAD:2006: BP: Leucocytes I 18
LYMPHOCYTES:
IMMUNOCYTES
Physiological Classification:T
and B
‘T’ LYMPHOCYTES :
cells
Responsible for Cell
mediated immunity.
Provide protection against
intracellular pathogens
NOMAD:2006: BP: Leucocytes I 19
LYMPHOCYTES: IMMUNOCYTES:
‘B’ LYMPHOCYTES
Trained in the Bone
marrow(Bursa Fabricius in
birds)
Responsible for Humoral
Immunity.(Immunity through
Antibody production)
Protect the body from
encapsulated pyogenic
bacteria like Pneumococcus &
streptococci.
NOMAD:2006: BP: Leucocytes I 20
NOMAD:2006: BP: Leucocytes I 21
LEUCOCYTES: REVIEW
Mobile units of Body
defence.
Classified into:
Granulocytes:
Eosinophils.
Basophils &
Neutrophils
Agranulocytes:
Monocytes
Lymphocytes:
Diapedesis
Amoeboid
movement
Chemotaxis
Phagocytosis.
NOMAD:2006: BP: Leucocytes I 23
LEUCOCYTES: REVIEW
Chemotaxis: Directed movement
Chemotaxins: Cytotaxins &
Cytotaxigens
Eosinophils: Spectacle shaped
nucleus, Coarse pink granules.
Basophils: Coarse blue granules,
obscuring nucleus. Custard apple
appearance.
Lymphocytes: Physiologically T and B
types.Responsible for immunity:
Immunocytes.