Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Standard view
Full view
of .
Save to My Library
Look up keyword
Like this
0 of .
Results for:
No results containing your search query
P. 1
Nano Particles With Honeycomb Cavities Containing Drugs Blast Cancer Cells

Nano Particles With Honeycomb Cavities Containing Drugs Blast Cancer Cells

Ratings: (0)|Views: 76 |Likes:
Published by Dr. Bob Glass
delivering using nano particles
delivering using nano particles

More info:

Categories:Types, Research
Published by: Dr. Bob Glass on Apr 22, 2011
Copyright:Attribution Non-commercial


Read on Scribd mobile: iPhone, iPad and Android.
download as PDF, TXT or read online from Scribd
See more
See less





4/22/11 10:41 AMNano Technology Group News | LinkedInPage 1 of 3http://www.linkedin.com/news?viewArticle=&articleID=483537004&g…114208%2Ehtm&urlhash=YKsF&goback=%2Egde_1031077_member_51243124
See Also:Health & Medicine
Lung Cancer Cancer Prostate Cancer 
Matter & Energy
NanotechnologyBiochemistryOrganic Chemistry
NanomedicineNatural killer cellNanoparticleMonoclonalantibody therapy
ScienceDaily (Apr. 20, 2011)
— Meldingnanotechnology and medical research, SandiaNational Laboratories, the University of NewMexico, and the UNM Cancer Research andTreatment Center have produced an effectivestrategy that uses nanoparticles to blast cancerouscells witha mélange of killer drugs.
In the cover article of the May issueof 
Nature Materials
, available onlineApril 17 , the researchers describesilica nanoparticles about 150nanometers in diameter ashoneycombed with cavities that canstore large amounts and varieties of drugs."The enormous capacity of thenanoporous core, with its highsurface area,combined with theimproved targeting of anencapsulatinglipid bilayer [called aliposome], permit a single 'protocell'loaded with a drug cocktail to kill adrug-resistant cancer cell," saysSandia researcher and UNMprofessor Jef Brinker, theprincipal investigator."That's a millionfold increase in efficiency over comparable methods employingliposomes alone -- withoutnanoparticles -- as drug carriers."The nanoparticles and thesurrounding cell-like membranesformed from liposomes together become the combinationreferred to as a protocell: the membrane seals in the deadlycargo and is modified with molecules (peptides) that bindspecifically to receptors overexpressed on the cancer cell'ssurface. (Too many receptors is one signal the cell iscancererous.) The nanoparticles provide stability to thesupported membrane and contain and release the therapeuticcargo within the cell.A current Food and Drug Administration-approvednanoparticle delivery strategy is to use liposomes themselvesto contain and deliver the cargo. In a head-to-headcomparison of targeted liposomes and protocells with identicalmembrane and peptide compositions, Brinker and colleaguesreport that the greater cargo capacity, stability and targetingefficacy of protocells leads to many times greater cytotoxicity[destruction] directed specifically toward human liver cancer cells.Another advantage to protocells over lipsomes alone, sayslead author Carlee Ashley, a Harry S. Truman post-doctoralfellow at Sandia's California site in Livermore, is thatliposomes used as carriers need specialized loadingstrategies that make the process more difficult. "We'vedemonstrated we can just soak nanoparticles to load themwith unique drug combinations needed for personalizedmedicine. They effectively encapsulate toxins as well assiRNA [ribonucleic acid] that silence expressions of proteins."RNA, the biological messenger that tells cells which proteins
The figure on the left (Hep3B) shows a greenly fluoresced cancerous liver cell penetrated by  protoc ells. The small red dots are lipid bilayer wrappi ngs. Their cargo — drug-fill ed nanoparticles,their pores here filled with white f luorescent dyes for i maging purposes — penetrat e the cancerous cell.(P enetration is more clearly seen in the second image.) The normal cell on the right (hepatocyte) shows no penetration. (Credit: Imagecour tesy of DOE/Sandia National Laboratories)
Related Stories
New 'Pyrex' Nanoparticle MoreStable In Harsh Environments
 (Sep.10, 2008)— Researchers inSwitzerland have developed a newmethod to fabricate borosilicate glassnanoparticles. Used in microfluidic systems, these"Pyrex"-like nanoparticles are more stable whensubjected to ... >
read more
Easing Concerns About A Promising NewMedical Imaging Agent
 (Aug. 20, 2007)— In astudy that eases concern about the toxicity of nanoparticles being considered for use in medicalimaging and biomedical research, scientists arereporting "no significant toxic effects" from ...>
read more
New Nanomaterials ToDeliver Anticancer Drugs To CellsDeveloped
 (June 8,2007)— Researchers report a novel approachusing silica-based nanoparticles for the delivery of camptothecin and other water-insoluble drugs intohuman cancer cells. They manipulatednanomaterials to create ... >
read more
Behavior Modification Could EaseConcerns About Nanoparticles
(Nov. 13, 2009)— In an advancethat could help ease health andenvironmental concerns about the emergingnanotechnology industry, scientists are reportingdevelopment of technology for changing thebehavior of ... >
read more
Nanoarticles Hitchhike On Red Blood
Nanoparticles With Honeycomb CavitiesContaining Drugs BlastCancer Cells
Breaking NewsFree Subscriptions
Just In:
Learning to Tolerate Our Microbial Self 
Science Video News
Unraveling Brain Tumors
Brain tumor researchers have foundthat brain tumors arise from cancer stem cells living within tiny protectiveareas formed by blood vessels inthe. ... >
full story 
Chemical Engineers Call On Nanoparticles ToCombat Polluted Groundwater Biomedical Engineers' 'Body-on-a-Chip' CouldReduce Cost of Developing New DrugsPediatric Cardiologists Show Hormone TherapyReduces Cancer Treatment Side Effects
more science videos... from NewsDaily.com
Scientistsmanipulatemosquitoes inmalaria fightU.S. hi-tech energyunit extends life in budget dealScientists take steps to making "bionic" legNASA clears shuttle Endeavour for April 29launch
more science news
In Other News ...
"Restrepo" director killed in Libya: doctorsSarkozy tells Libyan rebels: "We will help you"Gold breaks $1,500 as investors seek securityU.S. recommends death penalty in USS ColeattackSpecial Report: From Hannibal Lecter to BernieMadoff Lobbying push targets lawmakers on debt voteTrue Finns see Portugal bailout oppositiongrowingAt Facebook headquarters, Obama seeks 2008magic
more top newsCopyright Reuters 2008. SeeRestrictions.... from ScienceDaily 
Get the latest science news with our free emailnewsletters, updated daily and weekly. Or viewhourly updated newsfeeds in your RSS reader:Email NewslettersRSS Newsfeeds
Science News
Share Blog Cite Print Bookmark Email
Health & MedicineMind & BrainPlants & AnimalsEarth & ClimateSpace & TimeMatter & EnergyComputers & MathFossils & Ruins  
4/22/11 10:41 AMNano Technology Group News | LinkedInPage 2 of 3http://www.linkedin.com/news?viewArticle=&articleID=483537004&g…114208%2Ehtm&urlhash=YKsF&goback=%2Egde_1031077_member_51243124
Email or share this story:
|Moreto manufacture, in this case is used to silence the cellular factory, a way of causing apoptosis or cell death. "Si" is shortfor "silence."The lipids also serve as a shield that restricts toxicchemotherapy drugs from leaking from the nanoparticle untilthe protocell binds to and takes hold within the cancer cell.This means that few poisons leak into the system of thehuman host, if the protocells find no cancer cells. Thiscloaking mitigates toxic side effects expected fromconventional chemotherapy.Instead, the particles -- crafted small enough to float under the radar of the liver and other cleansing organs -- cancirculate harmlessly for days or weeks, depending on their engineered size, seeking their prey.A library of phages -- viruses that attack bacteria -- wascreated at UNM's nationally accredited cancer center bycollaborator David Peabody. This permitted researchers toexpose the phages to a group of cancerous cells and normalcells, allowing identification of peptides that bind specifically tocancer cells but not normal cells."Proteins modified with a targeting peptide that binds to aparticular carcinoma exhibit a 10,000-fold greater affinity for that cancer than for other unrelated cells," Ashley said.
Boosting medicine with nanotechnology strengthens drug cocktail many times over 
Brinker adds, "A key feature of our protocell is that its fluidbilayer allows high-affinity binding with just a few of thesepeptides overall. This reduces nonspecific binding andimmune response."The method is being tested on human cancer cells in vivo,and will shortly be tested on mouse tumors at UNM's cancer center.The researchers continue to optimize the size of the poroussilica particle, which is formed by aerosolizing a precursor solution. The porous nanoparticle fabrication process -- calledevaporation-induced self-assembly, and pioneered in theBrinker lab -- produces particles from 50 nanometers toseveral microns in diameter. Particle sizes between 50 and150 nanometers in diameter are ideal for maximizingcirculation and uptake into cancer cells, so the particles arepreselected by size before their formation into protocells."Their overall dimensions determine how widely they'll bedistributed in the bloodstream," Brinker said. "We're alteringour synthesis to favor the smaller sizes."Also of importance to the circulation time of the particle are itselectrical charge and hydrophobicity [avoidance of water],which can improve or detract from its ability to remain free of unwanted molecular or energetic entanglements.The method may be commercially available in five years,researchers estimate.Brinker is a Sandia Fellow and UNM Regent's andDistinguished Professor of Chemical and Nuclear Engineeringand member of UNM's cancer center.Other institutions involved in the research include theUniversity of California Davis, and the University of Waterlooin Canada.Funding was provided by the National Cancer Institute (NCI),the National Science Foundation, the Department of Energy'sBasic Energy Sciences program, the Air Force Office of Scientific Research, and Sandia's Laboratory DirectedResearch and Development office.The work is the first to show targeted delivery of nanoparticlesto cancers that is supported in part by a grant from NCI'sAlliance for Nanotechnology in Cancer.
Story Source: Cells: A Potential New Method For DrugDelivery
 (June 28, 2007)— Polymericnanoparticles are excellent carriers for delivering drugs. However, they are quicklyremoved from the blood, sometimes in minutes,rendering them ineffective in delivering drugs. Thisstudy ... >
read more
Carbon-Coated Nanomagnets Could Be A NewForm Of Cancer Treatment
 (May 17, 2008)Carbon-coated nanomagnets may offer a newform of cancer treatment. New research suggeststhat nanoparticles consisting of metallic iron with aprotective carbon coat could serve as a safe and... >
read more
Toward A Nanomedicine For Brain Cancer 
(Sep. 9, 2009)— In an advance toward better treatments for the most serious form of braincancer, scientists in Illinois are reportingdevelopment of the first nanoparticles that seekout and destroy brain cancer ... >
read more
Gold Nanoparticles Could Improve AntisenseCancer Drugs
 (May 19, 2006)— In the fightagainst cancer, antisense drugs, which preventgenes from producing harmful proteins such asthose that cause cancer, have the promise to bemore effective than conventional drugs, but ...>
read more
Your Name:Your Email:Comments:Click button to submit feedback:
Send It
... we want to hear from you! 
Tell us what you think of ScienceDaily -- wewelcome both positive and negative comments.Have any problems using the site? Questions?

You're Reading a Free Preview

/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->