Professional Documents
Culture Documents
– Rutgers University
April 27, 2011
Memory
Language
Spatial perceptions
Executive functions
◦ Judgment
◦ Problem solving
Behavior
◦ Attention
◦ Depression
◦ Aggression
◦ Apathy
Plaques
Tangles
Synaptic loss
Cell loss
◦ Hippocampus
◦ Basal nucleus
◦ Locus coeruleus
◦ Dorsal raphe
◦ …and beyond
Chronic inflammation
Plaques
◦ Fragments of the
APP protein
Tangles
◦ Hyper
phosphorylated tau
Synaptic loss
Cell loss
Inflammation
Genes/Loci
APP
(HC21)
Early-Onset PSEN1
AD Familial (30s-50s) (HC14)
Late-Onset PSEN2
Risk factor genes (HC1)
Trisomy 21
APOE APP Dup.
Sporadic (HC19) (30s-40s)
(80s)
Amyloid Precursor Protein
APP 751/770 KPI insert Aβ
Lipid Bilayer
NH2 COOH
695
Lipid Bilayer
Aβ peptide (40-42aa)
Hippocampal neuron
Alzheimer's disease case
Yang et al (2001)
Neuronal cycling matches human anatomy
PCNA NeuN Merge