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Heneka

Heneka

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Published by WorldEventsForum

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Categories:Types, Research, Science
Published by: WorldEventsForum on Apr 27, 2011
Copyright:Attribution Non-commercial

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07/10/2013

 
Michael T. Heneka, Clinical Neuroscience, Dept. of Neurology, University of Bonn
 
Sastre et al. J Neurosci 2003, PNAS 2006
BACE1 protein
*
0102030
BACE 1 activity
*
     %    o     f    c    o    n    t    r    o     l
Astro and microglial activationA
1-42
sOGs
A
1-40
A
1-42
 
release ofinflammatorycytokinesA
BACE1 mRNA
BACE1
 
γ
SEC
 
ADMCI
LC integrityWhen and why does LC dysfunction and degeneration starts?
Day 0Day 42LC derived norepinephrine suppressesneuroinflammation and upregulatesmicroglial migration and Aß uptakehenceits early degeneration – showing an almostcomplete loss in MCI brains allows for ahigher degree of inflammtion in LCprojection areas such as the neocortex andhippocampus

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