causing stiffness and rigidity of individual cells, reducing the cellsfunction in taking nutrients and expelling waste.If the cross link protein glycosylation occurs in the elastin andcollagen, it will cause brittle skin, causing aging, but it happens in theorgans it will be more serious and sometimes life threatening.
4. The neuroendocrine theory
First proposed by Professor Vladimir Dilman and Ward Dean MD,this theory postulates on wear and tear of the neuroendocrine system.In neuroendocrine system, the master pituitary gland secrets hormonesto direct other glands in secreting their hormones and worksconjunction with the hypothalamus glands form a command post inthe nervous system in closely direct the function of most of the bodyfunctions. but as we age, the hypothalamus loses its ability as a hormoneregulator as its receptors of which uptake other gland hormones become less sensitive to them, including sex hormones, DHEA,serotonin, melatonin, etc.As for cortisol, a hormone secreted by the adrenal glands due to stress,is produced with abundance as we age.
5. Immune system decline theory
As we age, our immune system is weakening that cause us becomevulnerable to the dangerous pathogens, including microbial and viralinvasion. Within the immune system, the thymus glands which playan important role in helping formation of the immune systemscavenger that reduces the function of immune system further thatallow irregular cell growth cause of aging spot, tumors, cancer,infection, inflammation and onset of chronic illness.
6. Genetic programming theory
Genetic programming theory propose that aging is programmed as thecells cycle in our body are also genetic program since their inception.the explanation is that all the cells are undergoing certain time indivision over the a said amount of time before dying, leading toconclusion that people with the long live genetic program live longer than others who do not.The theory also emphasizes the genetic diseases as a result of genetic programming diminished life span, regardless external and internalinfluence.