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Cannabis Studies and Case Reports

Cannabis Studies and Case Reports

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Published by Zen Chu

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Published by: Zen Chu on May 09, 2011
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Studies and Case Reports
Last update: 27 April 2011
You will find scientific information on most of the studies at Database on Clinical Studies and Case Reports
 
Improvement of symptoms or positive evaluation by authors
o
 
 No relevant change of symptoms or negative evaluation by authors
 
Deterioration of symptoms
Content
 Nausea and Vomiting – Cancer Chemotherapy ............................................................................... 3 Nausea and Vomiting – Radiotherapy ............................................................................................. 5 Nausea and Vomiting – Metastases ................................................................................................. 6 Nausea and Vomiting – Surgery ...................................................................................................... 6 Nausea and Vomiting – HIV/AIDS ................................................................................................. 6 Nausea and Vomiting – Therapy of Hepatitis C .............................................................................. 6 Nausea and Vomiting – Pregnancy .................................................................................................. 7 Nausea and Vomiting – Motion Sickness ........................................................................................ 7 Nausea and Vomiting – Other .......................................................................................................... 7 Nausea and Vomiting – Healthy Subjects ........................................................................................ 7Appetite Loss – HIV/AIDS .............................................................................................................. 7Appetite Loss – Cancer .................................................................................................................... 8Appetite Loss – Alzheimer's Disease ............................................................................................... 9Appetite Loss – Geriatrics ................................................................................................................ 9Appetite Loss - Anorexia nervosa .................................................................................................. 10Appetite Loss – COPD ................................................................................................................... 10Appetite Loss – Healthy Subjects .................................................................................................. 10Spasticity – Multiple Sclerosis ....................................................................................................... 10Spasticity – Spinal Cord Injury ...................................................................................................... 12Spasticity – Different Causes ......................................................................................................... 12Pain – Chronic, Neuropathic/Multiple Sclerosis ............................................................................ 13Pain – Chronic, Cancer ................................................................................................................... 15Pain – Rheumatic ........................................................................................................................... 16Pain - Fibromyalgia ........................................................................................................................ 16Pain – Chronic ................................................................................................................................ 16Pain – Acute, Surgery ..................................................................................................................... 18Pain – Acute, Healthy Subjects ...................................................................................................... 18Headache/Migraine ........................................................................................................................ 19Amyotrophic Lateral Sclerosis ....................................................................................................... 19Bladder Dysfunction ...................................................................................................................... 19Gastro-Oesophageal Reflux ........................................................................................................... 20Irritable Bowel Syndrome, Diarrhoea ............................................................................................ 20Obstetrics and Gynecology ............................................................................................................ 20Tremor ............................................................................................................................................ 20Dystonia ......................................................................................................................................... 20L-Dopa-induced Dyskinesia (Tardive Dyskinesia) ........................................................................ 21
 
Hiccups (Singultus) ........................................................................................................................ 21Tourette's Syndrome, Tics .............................................................................................................. 21Hyperkinetic Movement Disorder .................................................................................................. 22Attention-Deficit/Hyperactivity Disorder ...................................................................................... 22Obsessive Compulsive Disorder .................................................................................................... 22Parkinson's Disease ........................................................................................................................ 22Huntington's Disease ...................................................................................................................... 23Traumatic Brain Injury ................................................................................................................... 23Tinnitus........................................................................................................................................... 23Pruritus ........................................................................................................................................... 23 Night Sweats .................................................................................................................................. 24Epilepsy .......................................................................................................................................... 24Isaacs' Syndrome ............................................................................................................................ 24Intraocular Pressure - Glaucoma .................................................................................................... 25Intraocular Pressure - Healthy Subjects ......................................................................................... 25 Night Vision ................................................................................................................................... 26Asthma ........................................................................................................................................... 26Bronchodilation - Healthy Subjects ............................................................................................... 27COPD (Chronic Obstructive Pulmonary Disease) ......................................................................... 27Blood Pressure/Hypertension ......................................................................................................... 27Cancer ............................................................................................................................................. 27Alzheimer's Disease ....................................................................................................................... 27 Neuroprotection .............................................................................................................................. 28Schizophrenic Psychosis ................................................................................................................ 28Bipolar Disorder ............................................................................................................................. 29Depression ...................................................................................................................................... 29Anxiety ........................................................................................................................................... 29Posttraumatic Stress Disorder ........................................................................................................ 29Alcohol Dependency ...................................................................................................................... 30Opioid Dependency ........................................................................................................................ 30Cocaine/Crack Dependency ........................................................................................................... 30Cannabis Dependency .................................................................................................................... 30Sleep ............................................................................................................................................... 31Different Diseases .......................................................................................................................... 31
 
Nausea and Vomiting – Cancer Chemotherapy
Controlled Studies
Dronabinol
 
Artim R, DiBella N. Tetrahydrocannabinol (THC) plus prochlorperazine (PCZ) for refractory nauseaand vomiting (N/V). Proceedings of the American Society for Clinical Oncology 1983;2:84.
 
Chang AE, Shiling DJ, Stillman RC, Goldberg NH, Seipp CA, Barofsky I.Delta-9-tetrahydrocannabinol as an antiemetics in cancer patients receiving high-dose methotrexate.Annals of Internal Medicine 1979;91:819-824.
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Chang AE, Shiling DJ, Stillman RC, Goldberg NH, Seipp CA, Barofsky I, Rosenberg SA.. A prospective evaluation of delta-9-tetrahydrocannabinol as an antiemetic in patients receivingadriamycin and cytoxan chemotherapy. Cancer 1981; 47: 1746-1751.
 
Colls BM, Ferry DG, Gray AJ, Harvey VJ, McQueen EG. The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy. New Zealand Medical Journal 1980;91:449-451.
 
Ekert H, Waters KD, Jurk KH, Mobilia J, Loughnan P. Ameriloration of cancer chemotherapy-inducednausea and vomiting by delta-9-tetrahydrocannabinol. Medical Journal of Australia 1979;2:657-659.
 
Frytak S, Moertel CG, O'Fallon JR, Rubin J, Creagan ET, O'Connnell MJ. Delta-9-tetrahydrocannabinolas an antiemetics for patients receiving cancer chemotherapy. A comparison with prochlorperazine anda placebo. Annals of Internal Medicine 1979;91:825-830.
 
Gralla RJ, Tyson LB, Bordin LA, Clark RA, Kelsen DP, Kris MG. Antiemetic therapy: a review of recent studies and a report of a random assignment trial comparing metoclopramide withdelta-9-tetrahydrocannabinol. Cancer Treatment Report 1984;68:163-172.
 
Kluin-Nelemans JC, Nelemans FA, Meuwissen OJATh, Maes RAA.
9
-tetrahydrocannabinol (THC) asan antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo. Veterinary and Human Toxicology 1979;21:338-340.
 
Lane M, Vogel CL, Ferguson J, Krasnow S, Saiers JL, Hamm J. Dronabinol and prochlorperazine incombination for treatment of cancer chemotherapy-induced nausea and vomiting. Journal of Pain andSymptom Management 1991;6:352-359.
 
Levitt M, Faiman C, Hawks R, Wilson A. Randomized double blind comparison of delta-9-tetrahydroicannabinol (THC) and marijuana as chemotherapy antiemetics. Proceedings of theAmerican Society for Clinical Oncology 1984;3:91.
 
Levitt M, Wilson A, Bowman D, Faiman C, Kemel S, Krepart G. Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics. Proceedings of theAmerican Society for Clinical Oncology 1981;22:422.
 
McCabe M, Smith FP, Goldberg D, Macdonald J, Woolley PV, Warren R. Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy. Investigational New Drugs1988;6:243-246.
 
 Neidhart JA, Gagen MM, Wilson HE, Young DC. Comparative trial of the antiemetic effects of THCand haloperidol. International Journal of Clinical Pharmacology Research 1981; 21: 38-42S.
 
Orr LE, McKernan JF, Bloome B. Antiemetic effect of tetrahydrocannabinol. Compared with placeboand prochlorperazine in chemotherapy-associated nausea and emesis. Archives of Internal Medicine1980;140:1431-433.
 
Sallan SE, Cronin C, Zelen M, Zinberg NE. Antiemetics in patients receiving chemotherapy for cancer.A randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. New England Journalof Medicine 1980;302:135-138.
 
Sallan SE, Zinberg NE, Frei E. Antiemetic effect of delta-9-tetrahydrocannabinol in patients receivingcancer chemotherapy. New England Journal of Medicine 1975;293:795-797.
 
Ungerleider JT, Andrysiak T, Fairbanks L, Goodnight J, Sarna G, Jamison K. Cannabis and cancer chemotherapy. A comparison of oral delta-9-THC and prochlorperazine. Cancer 1982;50:636-645.
 
Ungerleider JT, Sarna G, Fairbanks LA, Goodnight J, Andrysiak T, Jamison K. THC or compazine for 

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