Five Major Contributors
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Inammation is a necessaryresponse or healing andsurvival. However, continualexposure to the inammatoryresponse is a primary cause o joint disease.Free radicals can degradethe hyaluronic acid in synovialuid, which results in losso viscosity and can impairthe joint’s ability to movesmoothly without riction.The hallmark o osteoarthritisis deterioration o articularcartilage, generally byenzymatic degradation o type II collagen and aggrecanby enzymes known asaggrecanase enzymes.Although exercise is importantor the growth and maintenanceo healthy joints, overuse andexercise-related injuries are otencontributors to the development o joint disease.Everyday activity and exercisecontributes to normal wearand tear on the joints. Chronicexposure to ree radicals andinammation also speedsthe aging process.
FREERADICALDAMAGEDEGRADATIVEENZYMEACTIVITY TRAUMATICINJURY OROVERUSENATURAL AGINGPROCESS
Enzymatic ActivityInfammationFree Radical DamageTraumatic Injury or OveruseLow-Grade Damage