Clinical Immunology

Sections

An Introduction: The Immune System
THE IMMUNE SYSTEM
GENERAL FEATURES
INNATE IMMUNE RESPONSES
CELLS THAT FUNCTION IN INNATE IMMUNE RESPONSES
CELLS THAT FUNCTION IN ADAPTIVE IMMUNE RESPONSES
TISSUES OF THE IMMUNE SYSTEM: GENERAL FEATURES
TISSUES OF THE IMMUNE SYSTEM: PRIMARY LYMPHOID ORGANS
TISSUES OF THE IMMUNE SYSTEM: SECONDARY LYMPHOID TISSUES
1SOLUBLE MEDIATORS OF THE IMMUNE SYSTEM
MOLECULES THAT ACTIVATE LYMPHOCYTES
MOLECULES THAT ACTIVATE LYMPHOCYTES: MONOCLONAL ACTIVATORS
MOLECULES THAT ACTIVATE LYMPHOCYTES: OLIGOCLONAL ACTIVATORS
MOLECULES THAT ACTIVATE LYMPHOCYTES: POLYCLONAL ACTIVATORS
SUMMARY
CLINICAL CASES AND DISCUSSION
TEST YOURSELF
Innate Immune Responses to Pathogens
Innate Immune Responses to Pathogens
OBJECTIVES
INNATE IMMUNE RESPONSES TO PATHOGENS
ROLE OF COMPLEMENT
PHAGOCYTOSIS
GENETIC DEFECTS IN NADPH OXIDASE: CHRONIC GRANULOMATOUS DISEASE
NATURAL KILLER CELLS
EOSINOPHILS
Antigen Presenting Cells
ANTIGEN PRESENTING CELLS
ANTIGEN PRESENTING MOLECULE: CLASS I MHC MOLECULES
ANTIGEN PRESENTING MOLECULES: CLASS II MHC MOLECULES
ANTIGEN PRESENTING MOLECULES: CD1 MOLECULES
Soluble Mediators of Immunity I: Antibodies
ANTIBODIES
GENERAL FEATURES OF ANTIBODIES
STRUCTURE FUNCTION RELATIONSHIP OF ANTIBODIES
PROPERTIES OF IMMUNOGLOBULIN ISOTYPES
MONOCLONAL ANTIBODIES
MONOCLONAL ANTIBODIES AS THERAPEUTIC AGENTS
CLINICAL TRIALS
Soluble Mediators of Immunity II: Complement
COMPLEMENT
COMPLEMENT PATHWAYS: GENERAL FEATURES
COMPLEMENT BIOLOGICAL ACTIVITIES
COMPLEMENT REGULATION
COMPLEMENT AND COAGULATION PATHWAYS ARE LINKED VIA KALLIKREIN
COMPLEMENT GENETIC DEFICIENCIES
ROLE OF COMPLEMENT IN MEDICINE
XENOTRANSPLANTATION: COMPLEMENT IS DELETERIOUS
Soluble Mediators of Immunity III: Cytokines
CYTOKINES
CYTOKINE RECEPTORS THAT ENGAGE THE JAK/STAT PATHWAY
CYTOKINE RECEPTORS THAT ENGAGE SMADS
CLINICAL RELEVANCE OF CYTOKINES
CHEMOKINES
Cells of Adaptive Immunity
B-LYMPHOCYTE ANTIGEN-SPECIFIC RECEPTOR
CONSTRUCTING AN IMMUNOGLOBULIN
B-CELL DIFFERENTIATION: BONE MARROW
CLINICAL SIGNIFICANCE: B-CELL NEOPLASMS
T-LYMPHOCYTE ANTIGEN-SPECIFIC RECEPTOR
DIFFERENTIATION OF LYMPHOID PROGENITOR CELLS IN THE THYMUS
TO SECONDARY LYMPHOID TISSUES
Antigen Dependent B-cell Differentiation
ANTIGEN DEPENDENT B-CELL DIFFERENTIATION
FATE OF ACTIVATED B CELLS IN GERMINAL CENTERS
PRIMARY VERSUS SECONDARY IMMUNE RESPONSES
CLINICAL SIGNIFICANCE
MODEL OF SIGNAL TRANSDUCTION IN B-CELL ACTIVATION
NEGATIVE SIGNALING IN B CELLS
B-CELL RESPONSES TO T-INDEPENDENT ANTIGENS
CD4+ T CELLS: ANTIGEN INDUCED DIFFERENTIATION
MEMORY CD4+ T CELLS
CLINICAL RELEVANCE OF TYPE 1 VERSUS TYPE 2 CYTOKINES
CD8+ T CELLS: ANTIGEN INDUCED DIFFERENTIATION
MEMORY CD8+ T CELLS
CLINICAL RELEVANCE CD8+ T CELLS
MODEL OF SIGNAL TRANSDUCTION IN T-CELL ACTIVATION
NEGATIVE REGULATION OF T-CELL SIGNALING
GAMMA/DELTA T CELLS
INFLAMMATION
VASODILATATION, INCREASED VASCULAR PERMEABILITY
OF INFLAMMATION
ADAPTIVE IMMUNE RESPONSES IN INFLAMMATION
ROLE OF INNATE AND ADAPTIVE IMMUNITY IN INFLAMMATION
Immunological Responses to Microbes
IMMUNITY TO MICROBES
HOST DEFENSES TO EXTRACELLULAR BACTERIA
General features
RESISTANCE TO IMMUNITY: EXTRACELLULAR BACTERIA
HOST DEFENSES TO VIRUSES
RESISTANCE TO IMMUNITY: HIV
HOST DEFENSES TO INTRACELLULAR BACTERIA
RESISTANCE TO IMMUNITY: INTRACELLULAR BACTERIA
HOST DEFENSES TO FUNGI
RESISTANCE TO IMMUNITY: FUNGI
IMMUNIZATION
PASSIVE IMMUNIZATION
ACTIVE IMMUNIZATION OR “VACCINATION”
FORMS OF VACCINES
VACCINE EFFICACY AND SAFETY
SUCCESSFUL APPLICATION OF VACCINE TECHNOLOGY
LIMITED USE VACCINES AND EXPERIMENTAL VACCINES
USES OF VACCINES (FOR OTHER THAN CONTROL OF INFECTION)
Hypersensitivity Reactions
HYPERSENSITIVITY REACTIONS
TYPE I: IMMEDIATE HYPERSENSITIVITY REACTIONS
TYPE II: ANTIBODY-MEDIATED HYPERSENSITIVITY REACTIONS
TYPE III: IMMUNE-COMPLEX MEDIATED HYPERSENSITIVITY
TYPE IV: CELL-MEDIATED HYPERSENSITIVITY
AUTOIMMUNITY
TOLERANCE INDUCTION
LOSS OF SELF-TOLERANCE
IMMUNOTHERAPY OF AUTOIMMUNE DISEASE: SUPPRESSION
IMMUNOTHERAPY OF AUTOIMMUNE DISORDERS: CYTOKINE MODULATION
Immunodeficiency Disorders
IMMUNODEFICIENCY DISORDERS
PRIMARY IMMUNODEFICIENCY DISORDERS
PRIMARY IMMUNODEFICIENCY DISORDERS: PROGENITOR CELLS
PRIMARY IMMUNODEFICIENCY DISORDERS: T CELLS
PRIMARY IMMUNODEFICIENCY DISORDERS: B CELLS
SECONDARY IMMUNODEFICIENCY DISORDERS
SECONDARY IMMUNODEFICIENCY DISORDERS: ACQUIRED
TUMOR IMMUNOLOGY
THE CONCEPT OF IMMUNOSURVEILLANCE
TUMOR ANTIGENS
TUMOR IMMUNOSURVEILLANCE
EFFECTOR MECHANISMS FOR ELIMINATION OF TUMORS
EVASION OF IMMUNE SURVEILLANCE
IMMUNOLOGY IN DIAGNOSIS OR IN MONITORING PROGNOSIS
BY DENDRITIC CELLS
INTO TUMOR CELLS THEMSELVES
NOVEL THERAPIES: MONOCLONAL ANTIBODIES AND IMMUNOTHERAPY
TRANSPLANTATION
CLASSIFICATION OF GRAFTS ACCORDING TO THEIR SOURCE
CLASSIFICATION OF GRAFT REJECTION
GENETICS OF TRANSPLANTATION
IMMUNOLOGY OF GRAFT REJECTION
TISSUE DIFFERENCES IN CLINICAL TRANSPLANTATION
GRAFT-VERSUS-HOST DISEASE
IMMUNOSUPPRESSION IN TRANSPLANTATION

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