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Table Of Contents

1. INTRODUCTION
2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS
3. TOXICOKINETICS RELEVANT TO ASSESSMENTS
3.1. ABSORPTION
3.1.1. Oral Exposure
3.1.2. Inhalation Exposure
3.3. METABOLISM
3.4. ELIMINATION
3.5. PHYSIOLOGICALLY-BASED TOXICOKINETIC (PBTK) MODELS
4. HAZARD IDENTIFICATION
4.1. STUDIES IN HUMANS
4.1.1. Oral Exposure
4.1.2. Inhalation Exposure
4.1.2.1. Acute Studies
4.1.2.2. Prechronic And Chronic Studies
4.1.2.3. Cancer Studies
4.2.1. Oral Exposure
4.2.1.1. Prechronic Studies
4.2.1.2. Chronic Studies
4.2.2. Inhalation Exposure
4.2.2.1. Prechronic Studies
4.2.2.2. Chronic Studies
4.3.1. Studies In Humans
4.3.2. Studies in Animals
4.3.2.1. Oral Exposure
4.3.2.2. Inhalation Exposure
4.4. OTHER STUDIES
4.4.1. Acute Toxicity Data
4.4.1.1. Oral Exposure
4.4.1.2. Inhalation Exposure
4.4.2. Genotoxicity
4.5.1. Oral Exposure
4.5.2. Inhalation Exposure
4.5.3. Mode of Action
4.6.1. Summary of Overall-Weight-of-Evidence
4.6.2. Synthesis of Human, Animal and Other Supporting Evidence
4.7. SUSCEPTIBLE POPULATIONS AND LIFE STAGES
4.7.1. Possible Childhood Susceptibility
4.7.2. Possible Gender Differences
4.7.3. Other
5. DOSE RESPONSE ASSESSMENTS
5.1. ORAL REFERENCE DOSE (RfD)
5.1.1. Choice of Principal Study and Critical Effect
5.1.2. Methods of Analysis
5.1.3. RfD Derivation - Including Application of Uncertainty Factors
5.1.4. Previous Oral Assessment
5.2. INHALATION REFERENCE CONCENTRATION (RfC)
5.2.1. Choice of Principal Study and Critical Effect
5.2.2. Methods of Analysis
5.2.3. RfC Derivation - Including Application of Uncertainty Factors
5.2.4. Previous Inhalation Assessment
5.3. CANCER ASSESSMENT
5.3.1. Choice of Study/Data
6.1. HUMAN HAZARD POTENTIAL
6.2. DOSE RESPONSE
6.2.1. Noncancer/Oral
6.2.2. Noncancer/Inhalation
6.2.3. Cancer/Oral and Inhalation
7. REFERENCES
Appendix B. Benchmark Dose Modeling Results for the Derivation of the RfD
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Toxicological Review of Toluene

Toxicological Review of Toluene

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Published by brigitta_carriel

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Published by: brigitta_carriel on May 31, 2011
Copyright:Attribution Non-commercial

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02/12/2013

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