Bioethical Considerationsfor Human Nutrigenomics
Manuela M. Bergmann,
Ulf G ¨orman,
and John C. Mathers
Department of Epidemiology, German Institute of Human Nutrition,Potsdam-Rehbr ¨ucke, D-14558 Germany; email: email@example.com
Department of Ethics, Lund University, SE-221 00 Lund, Sweden;email: firstname.lastname@example.org
Human Nutrition Research Center, Newcastle University, Newcastle upon Tyne,NE2 4HH United Kingdom; email: email@example.com Annu. Rev. Nutr. 2008.28:447–67First published online as a Review in Advance on April 25, 2008 The
Annual Review of Nutrition
is online atnutr.annualreviews.org This article’s doi:10.1146/annurev.nutr.28.061807.155344Copyrightc
2008 by Annual Reviews. All rights reserved0199-9885/08/0821-0447$20.00
ethics, nutrigenomics, human studies, personalized nutrition
This article gives an overview of the ethical issues in nutrigenomics re-searchandpersonalizednutrition.Theprinciplesofresearchethics,i.e.,autonomy, beneﬁcence, nonmalfeasance, and justice, are challenged by rapidly growing cross-border research activities utilizing existing andupcoming biobanks for studies of the interaction of genes with dieton risk of common diseases. We highlight the ethical issues, some un-resolved, in international collaborative projects of which researchersshould be aware. Personalized nutrition (tailoring diet on the basis of genotype) is one possible application of nutrigenomics research. How-ever, until the scientiﬁc evidence concerning diet–gene interactions ismuch more robust, the provision of personalized dietary advice on thebasis of speciﬁc genotype remains questionable. From the ethical andsocialperspective,nutrigenomicsofferssigniﬁcantopportunitiestoim-prove public health by enhancing understanding of the mechanismsthroughwhichdietcanbeusedtoreducetheriskofcommonpolygenicdiseases.
A n n u . R e v . N u t r . 2 0 0 8 . 2 8 : 4 4 7 - 4 6 7 . D o w n l o a d e d f r o m a r j o u r n a l s . a n n u a l r e v i e w s . o r g b y U N I V E R S I T Y O F I L L I N O I S - C H I C A G O o n 0 9 / 2 8 / 0 8 . F o r p e r s o n a l u s e o n l y .