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Table Of Contents

1. Epidemiology, Transmission and Natural History
Epidemiology
Transmission
Acute Hepatitis
Chronic Hepatitis
Natural History
Cirrhosis and Hepatic Decompensation
Disease progression
2. HCV - Structure and Viral Replication
Taxonomy and Genotypes
Viral Structure
Genome Organization
HCV Proteins
Viral Lifecycle
Adsorption and viral entry
Translation and posttranslational processes
HCV RNA replication
Assembly and release
3. Diagnostic Tests in Acute and Chronic Hepatitis C
Serologic Assays
Nucleic Acid Testing for HCV
HCV Genotyping
Implications for Diagnosis and Management
Diagnosing acute hepatitis C
Diagnosing chronic hepatitis C
Diagnostics in the management of therapy
4. Hepatitis C Standard of Care
Treatment Goals and Definitions
Drugs
Management of Chronic HCV Infection
Management of HCV genotype 2 and 3
Management of HCV genotype 1
Adherence
IL28B
Side effects
Interferon alfa (IFN)
Ribavirin
Special populations
Patients with normal aminotransferase levels
HCV and liver transplantation
Dialysis patients
Retreatment
Treatment of Acute Hepatitis C
Outlook
5. New Agents for Treating Hepatitis C
Telaprevir (VX-950)
Boceprevir (SCH 503034)
Ciluprevir (BILN 2061)
Other NS3-4A protease inhibitors
Resistance to NS3-4A protease inhibitors
Compounds Targeting HCV Replication
NS5B polymerase inhibitors
Nucleoside analogues
Non-nucleoside analogues
NS5A inhibitor
Combination therapies of specific antivirals
Host proteins as targets in treating hepatitis C
Cyclophilin B inhibitors
Nitazoxanide
Silibinin
Novel interferons
6. Adverse Events and Drug Interactions
Systemic Symptoms
Psychiatric Adverse Events
Haematologic and immunologic effects
Skin disorders
Telaprevir and Boceprevir
Conclusion
7. Extrahepatic Manifestations
Lymphoproliferative Disorders
Malignant Lymphoproliferative Disorders/NHL
Treatment of Lymphoproliferative Disorders
Other Haematological Manifestations
Dermatologic and Other Manifestations
8. Management of HCV/HIV Coinfection
Epidemiology of HIV and HCV Coinfection
Diagnosing HCV in HIV Coinfection
Effect of Hepatitis C on HIV Infection
Effect of HAART on Hepatitis C
Treatment
Antiretrovirals while on HCV therapy
Liver Transplantation in HIV/HCV-Coinfected Patients
9. Management of HBV/HCV Coinfection
Screening
Viral Interactions
10. References
11. Appendix
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FPG_002_HepatitisC (Short Guide to Hepatitis C , 2011 Edition Free)

FPG_002_HepatitisC (Short Guide to Hepatitis C , 2011 Edition Free)

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Published by: nightroller on Jun 10, 2011
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09/17/2012

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