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Uptake of Inhalational anaesthetics

Uptake of Inhalational anaesthetics

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Published by Deepak Solanki
uptake of inhalational anesthetic agents
uptake of inhalational anesthetic agents

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Published by: Deepak Solanki on Jun 12, 2011
Copyright:Attribution Non-commercial

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05/19/2012

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PTAKEOFINHALATIONAL
 
PTAKEOFINHALATIONALANESTHETICSNESTHETICS
DR.DEEPAK SOLANKIM.D. ANAESTHESIOLOGYdr.dsolanki@gmail.com
 
Pharmacokinetics
: Relationship between a drug'sdose tissue concentration and elapsed time.
Pharmacodynamics
: Drug action including toxicresponses.
Pharmacokinetics of inhaled anesthetic involves :
1.Absorption (uptake) from alveoli into pulmonarycapillary blood.
2.Distribution in the body
3.Metabolism
4.Elimination (lungs)
Aging : in lean body mass, in body fat apparent
VD
 
hepatic function and pulmonary gas exchange
 
Principal objective of inhalational anesthesiais to achieve a constant and optimal brainpartial pressure of inhaled anesthetic
PA Pa Pbr
PA is an indirect measurement of anestheticpartial pressure at brain.
 There are three steps:
1.Transfer of inhaled anestetic frommachine to alveoli
2.Transfer from alveoli to arterial blood
3.Transfer from arterial blood to brain
 These steps are influenced by various factors.

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