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Micro Encapsulation

Micro Encapsulation

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Published by GANESH KUMAR JELLA
WWW.BPHARMSTUF.COM
WWW.BPHARMSTUF.COM

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Categories:Types, Research
Published by: GANESH KUMAR JELLA on Jun 15, 2011
Copyright:Attribution Non-commercial

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05/09/2013

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SEMINAR ON
NEW MICROENCAPSULATION METHOD USING AN ULTRASONICATOMIZER BASED ON INTERFACIALSOLVENT EXCHANGE
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Microencapsulation
is defined as the process of enclosing micron sized particles of solidsor droplets of liquids or gasses in an inert shell, which in turn isolates and protects themfrom the external environment.Particle size below 1µm-nanoparticles, nanocapsules, nanospheresParticles diameter between 3 -800µm-micro particles or microcapsules or microspheres.Particles larger than 1000µm -macro particles.Micro particles or microcapsules consist of two components:Core materialCoating materialAdvantages:
to protect the sensitive substances from the external environment.
to mask the organoleptic properties like colour, taste, odour of the substance.
to obtain controlled release of the drug substance.
for safe handling of the toxic materials.
to get targeted release of the drug.
to avoid adverse effects like gastric irritation of the drug e.g. aspirin is the first drugwhich is used to avoid gastric irritation.
22
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Disadvantages:
Incomplete coating.
Inadequate stability of sensitive materials.
Non-reproducible and unstable release.
Economic limitations.Factors affecting the encapsulation effiency:Solubility of polymer in organic solventSolubility of organic solvent in waterConcentration of polymerRatio of dispersed phase to continuous phase (DP/CP ratio)Rate of solvent removalInteraction between the drug and polymerSolubility of drug in continuous phaseMolecular weight of polymer

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