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Featured Product of Selleck---GSK429286A(Purity>99%)

Featured Product of Selleck---GSK429286A(Purity>99%)

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Published by Selleck Chem
Technical Data:
M.Wt: 432.37
Formula: C21H16F4N4O2
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 864082-47-3
Biological Activity of GSK429286A:

GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor with an IC50 of 14 nM. Not only was GSK429286A a potent ROCK1 inhibitor, but GSK429286A also possessed exciting selectivity (30-fold) against a panel of 33 kinases, including RSK1 (IC50 = 3.1 μM) and p70S6K (Ic50 = 2.85μM). ROCKs are serine/threonine specific protein kinases which play a crucial role in organization of the actin cytoskeleton. ROCK inhibitors have been found to prevent apoptosis, as well as to enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. Because of GSK429286A's specificity, this reagent may be useful in assessing the cellular roles of individual ROCK isoforms.
Technical Data:
M.Wt: 432.37
Formula: C21H16F4N4O2
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 864082-47-3
Biological Activity of GSK429286A:

GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor with an IC50 of 14 nM. Not only was GSK429286A a potent ROCK1 inhibitor, but GSK429286A also possessed exciting selectivity (30-fold) against a panel of 33 kinases, including RSK1 (IC50 = 3.1 μM) and p70S6K (Ic50 = 2.85μM). ROCKs are serine/threonine specific protein kinases which play a crucial role in organization of the actin cytoskeleton. ROCK inhibitors have been found to prevent apoptosis, as well as to enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. Because of GSK429286A's specificity, this reagent may be useful in assessing the cellular roles of individual ROCK isoforms.

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Categories:Types, Research, Science
Published by: Selleck Chem on Jun 15, 2011
Copyright:Attribution Non-commercial

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