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Clinical Drug Therapy (Rationales for Nursing Practice)

Clinical Drug Therapy (Rationales for Nursing Practice)

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Published by Michael V.

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Published by: Michael V. on Jun 17, 2011
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05/12/2014

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Contents
SECTION 1
Introduction to Drug Therapy
. . . . . . . . . . . . . . . . . . . . . . . . . . . . .1
1
 Introduction to Pharmacology
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2
A Message to Students
2Overview2Sources of Drugs3Drug Classi
cations and Prototypes3Drug Names3Drug Marketing3Pharmacoeconomics4Prescription and Nonprescription Drugs4Drug Approval Processes4Sources of Drug Information7Strategies for Studying Pharmacology7
2
 Basic Concepts and Processes
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9
Overview9Cellular Physiology9Drug Transport Through Cell Membranes10Pharmacokinetics10Pharmacodynamics15Variables That Affect Drug Actions17Tolerance and Cross-Tolerance20Adverse Effects of Drugs20
3
 Administering Medications
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .29
Overview29General Principles of Accurate Drug Administration29Legal Responsibilities30Medication Errors30Medication Systems31Medication Orders31Drug Preparations and Dosage Forms32Calculating Drug Dosages34Routes of Administration35
4
 Nursing Process in Drug Therapy
. . . . . . . . . . . . . . . . . . . . . . . . . . . .47
Overview47Nursing Process in Drug Therapy48Integrating Nursing Process, Critical Paths and Drug Therapy51General Principles of Drug Therapy59
xvii
 
xviii
CONTENTS
SECTION 2
Drugs Affecting the Central Nervous System
. . . . . . . . . . .71
5
 Physiology of the Central Nervous System
. . . . . . . . . . . . . . . . . . . . . .72
Characteristics and Functions of the Central Nervous System72Drugs Affecting the Central Nervous System77
6
Opioid Analgesics and Opioid Antagonists
. . . . . . . . . . . . . . . . . . . . .79
Overview79Pain79Endogenous Analgesia System80Opioid Analgesics80Individual Drugs82Principles of Therapy89
7
 Analgesic–Antipyretic–Anti-inflammatory and Related Drugs
. . . . .99
Overview99Pain, Fever, and In
ammation100Mechanism of Action100Indications for Use102Contraindications to Use103Subgroups and Individual Drugs104Principles of Therapy114
8
 Antianxiety and Sedative-Hypnotic Drugs
. . . . . . . . . . . . . . . . . . . . .124
Overview124Anxiety125Sleep and Insomnia125Drugs Used to Treat Anxiety and Insomnia126Principles of Therapy134
9
 Antipsychotic Drugs
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .144
Psychosis144Schizophrenia145Antipsychotic Drugs145Principles of Therapy152
10
 Drugs for Mood Disorders: Antidepressants and Mood Stabilizers
. . . . . . . . . . . . . . . . . . . . . . . .163
Mood Disorders163Antidepressant Drugs165Types of Antidepressants and Individual Drugs166Principles of Therapy171
11
 Antiseizure Drugs
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .182
Seizure Disorders182Antiseizure Drugs183Individual Antiseizure Drugs184Principles of Therapy193
 
CONTENTS
xix
12
 Antiparkinson Drugs
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .202
Parkinson
s Disease202Antiparkinson Drugs202Individual Antiparkinson Drugs203Principles of Therapy207
13
Skeletal Muscle Relaxants
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .213
Skeletal Muscle Relaxants213Individual Drugs214Principles of Therapy217
14
 Anesthetics
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .220
General Anesthesia220Regional Anesthesia221Adjuncts to Anesthesia221Individual Anesthetic Agents222Principles of Therapy222
15
Substance Abuse Disorders
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .236
Substance Abuse236Dependence236Central Nervous System Depressants237Central Nervous System Stimulants243Principles of Therapy249
16
Central Nervous System Stimulants
. . . . . . . . . . . . . . . . . . . . . . . . . .251
Uses251Types of Stimulants252Individual Central Nervous System Stimulants252Principles of Therapy255
SECTION 3
Drugs Affecting the Autonomic Nervous System
. . . . . .260
17
 Physiology of the Autonomic Nervous System
. . . . . . . . . . . . . . . . . .261
Autonomic Nervous System261Characteristics of Autonomic Drugs266
18
 Adrenergic Drugs
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .268
Description268Individual Adrenergic Drugs272Principles of Therapy275
19
 Antiadrenergic Drugs
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .283
Description283Individual Antiadrenergic Drugs285Principles of Therapy290