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The Pathophysiology of Combined Radiation Injuries

The Pathophysiology of Combined Radiation Injuries

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Published by rlnac
The Pathophysiology of Combined Radiation Injuries
A Review and Analysis of the Literature on Non-Human Research
Defense Nuclear Agency July 1991
The Pathophysiology of Combined Radiation Injuries
A Review and Analysis of the Literature on Non-Human Research
Defense Nuclear Agency July 1991

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Published by: rlnac on Jun 21, 2011
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05/27/2012

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Defense
Nuclear
Agency
Alexandria,
VA
22310-3398
AD-A239
981
I
fllrlrfrlrliII
l
IfIlrlfillf1il
.,D
A-TR-90-2
11
The
Pathophysiologyof
CombinedRadiation
Injuries
A
Review
and
Analysis
of
the
Literature
on
Non-Human
Research
Siegmund
J.
Baum
Technico
Southwest,
Inc.
P.O.
Box
847
Los Alamos,
NM
87544
July
1991
.AG99~
TechnicalReport
CONTRACT
No.
DNA
001-88-C-0207
Approved
forpublic
release-
distribution
isunlimited.
91-08891
1
I iiI
 
Destroy
this
report
when
it
isno
longer
needed.
Do
not
return
to
sender.
PLEASE
NOTIFYTHE
DEFENSE
NUCLEAR
AGENCY,
ATTN:
CSTI,
68ui
TELEGRAPHROAD,
ALEXANDRIA,
VA
22310-3398,
IF
YOUR
ADDRESS
IS
INCORRECT,
IF
YOU
WISH
IT
DELETED
FROM
THE
DISTRIBUTION
LIST,
OR
IFTHE
ADDRESSEE
IS
NOLONGER
EMPLOYED
BY
YOUR
ORGANIZATION.
'S
@I14S
 
REPORT
DOCUMENTATION
PAGE
Form
Approved
R
DOMB
No.
0704-0188
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reporting burden
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tion
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Including
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existing
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nd
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Send comments
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tatone
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WashingtonHeadquarters Services,
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Operations
end
Reports,
1216 Jefferson
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to
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1.
AGENCY
USE
ONLY
(Leave
blank)
2.
REPORT
DATE
3.
REPORT
TYPE
AND
DATES
COVERED
1
910701
ITechnical
880928
-
900101
4.
TITLE
AND
SUBTITLE
6.
FUNDING
NUMBERS
The
Pathophysiology
of
Combined
Radiation
C
-DNA
001-88-C-0207
Injuries,
A
Review
andAnalysis
of
thePE-675
Literature
on
Non-HumanResearch
FIR
-
6215
.
AUTHOR(S)
TA
-
RH
Siegmund
J.
Baum
WU
-
DH050880
7.
PERFORMING
ORGANIZATION
NAME(S)
AND
ADDRESS(ES)
8.
PERFORMING
ORGANIZATION
Technico
Southwest,
Inc.
REPORT
NUMBER
P.O.Box
847
Los
Alamos,
NM 87544
9.
SPONSORING/MONITORING
AGENCY
NAME(S)AND
ADDRESS(ES)
10.SPONSORING/MONITORING
Defense
Nuclear
Agency
AGENCY
REPORT
NUMBER
6801
Telegraph
RoadDNA-TR-90-211Alexandria,
VA
22310-3398
RARP/Kehlet
11.
SUPPLEMENTARY
NOTES
This
work
was
sponsored
by
the
Defense
NuclearAgencyunder
RDT&E
RMC code
B4662D
RM
RH
00073RARP 3500A
25904D.
12a.
DISTRIBUTION/AVAILABILITY
STATEMENT
12b.
DISTRIBUTION
CODE
Approved
for
public release;
distribution
is
unlimited.
13.
ABSTRACT
(Maximum
200
words)
One
hundred
and
seventy
one
referencesapplicable
to
determining
the
effect
of
tacticalnuclear weapons
on
military personnel
have
beenreviewed,
and
the
signifi-antconclusions
are
reported.
Thestudy
reviews
the
scientific literature
and
focuses
on
animalexperiments
published
from1933
to
the
present
time,
including
a
number
of
German studies
and some
Sovietresearch
not
previouslyreviewed
in
Englishlanguagepublications.Recurring
themes
of
the
review
are
the
synergisticincrease
in
mortalitywhen
injury(burn,
wound,bleeding,fracture,
etc.)
followsirradiation
andthe
reduction
in
mortality
when injuryprecedesirradiation and/orwhen antibiotics
are
administered.
The
synergistic
increases
are
attributed
to
radiation
damage
tothe
bone
marrowprecursor
cells,
which
reduces
the
protectivemechanisms(leukopenia)
and
permits
easier
onset
of
bacteremia
and
septicemia.
14.
SUBJECT
TERMS
15.
NUMBER
OF
PAGES
Combined
Injuries
Blast
Injuries
106
Radiation
InjuriesThermal
Injuries
16
PRICECODE
17.
SECURITY
CLASSIFICATION
IS.
SECURITY
CLASSIFICATION
19.
SECURITY
CLASSIFICATION
20.
LIMITATION
OF
OF
REPORT
OF
THIS
PAGE
OF
ABSTRACTABSTRACT
UNCLASSIFIEDUNCLASSIFIEDUNCLASSIFIED
SAR
NSN
75400I.280-5500
Standard
Form
298
(Rev
2-89)
SPocribed
bv
ANSI
Ste
239
'8
29N
102

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