BI-WEEKLY Volume 24, Number 25 - June 24, 2011

NEW TREATMENT FOR TYPE 2

DIABETES APPROVED
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NEW TREATMENT FOR TYPE 2
DIABETES APPROVED
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New Medicine Approved By FDA To Treat Type 2 Diabetes
(ARA) - Diabetes (both type 1 and type 2) affects ap-
proximately 25.8 million Americans and an estimated
220 million people worldwide. Type 2 diabetes is the
most common type, accounting for an estimated 90 to 95
percent of diabetes cases. Diabetes is a chronic disease
that occurs when the body either does not properly pro-
duce, or use, the hormone insulin.
Now there is good news for people with type 2 dia-
betes. Boehringer Ingelheim Pharmaceuticals, Inc.
and Eli Lilly and Company announced the U.S. Food
and Drug Administration (FDA) recently approved
TRADJENTA(TM) (linagliptin) tablets, a new prescrip-
tion medication used along with diet and exercise, to
lower blood sugar in adults with type 2 diabetes.
TRADJENTA (pronounced TRAD gen ta) can be used
alone or with other commonly used medications for type
2 diabetes - metformin, sulfonylurea or pioglitazone.
TRADJENTA lowered hemoglobin A1C (HbA1C or
A1C) levels up to 0.7 percent (compared to placebo) in
clinical trials.
A1C is measured in people with diabetes to provide an
index of blood sugar control for the previous two to
three months.
TRADJENTA should not be used in patients with type
1 diabetes or for the treatment of diabetic ketoacidosis
(increased ketones in the blood or urine). It has not been
studied in combination with insulin.
Many people with type 2 diabetes are not able to con-
trol their blood sugar with diet and exercise alone and
may also require one or more medications, says Dr.
John Gerich, professor of medicine, at the University of
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Rochester School of Medicine. The FDA approval of
TRADJENTA is exciting because there is only one dose
to remember for patients, regardless of kidney or liver
impairment. With TRADJENTA, physicians will have
another option for managing type 2 diabetes, a poten-
tially devastating condition.
TRADJENTA is a tablet that can be taken once a day,
with or without food. It lowers blood sugar by increasing
incretin levels, which increase insulin levels after meals
and throughout the day.
It was approved based on a clinical trial program which
included approximately 4,000 adults with type 2 diabe-
tes. Included in the program were placebo-controlled
studies evaluating TRADJENTA alone and with other
commonly-used medications for type 2 diabetes.
TRADJENTA lowered fasting plasma glucose (FPG)
compared to placebo, when used as monotherapy and
in combination with metformin, sulfonylurea or piogli-
tazone. FPG is used to determine glucose levels in a fast-
ing state, usually upon waking up in the morning.
It also lowered two-hour post-prandial glucose (PPG)
levels compared with placebo as monotherapy and when
used in combination with metformin. PPG is used to de-
termine glucose levels after meals, usually two hours af-
ter eating.
To learn more about TRADJENTA and for full prescrib-
ing information visit: www.TRADJENTA.com or call
Boehringer Ingelheim Pharmaceuticals, Inc. at (800)
542-6257.
Please report any unexpected effects or product prob-
lems to the Boehringer Ingelheim Drug Information Unit
by calling (800) 542-6257.
What is TRADJENTA?
TRADJENTA is a prescription medicine that is used
along with diet and exercise to lower blood sugar in
adults with type 2 diabetes. TRADJENTA is not for peo-
ple with type 1 diabetes or for people with diabetic keto-
acidosis (increased ketones in the blood or urine).
It is not known if TRADJENTA(TM) (linagliptin) tab-
lets is safe and effective when used with insulin.
Important Safety Information
Who should not take TRADJENTA?
Do not take TRADJENTA if you are allergic to lina-
gliptin or any of the ingredients in TRADJENTA.
Symptoms of a serious allergic reaction to TRADJENTA
are rash, raised red patches on your skin (hives), swell-
ing of your face, lips, and throat that may cause diffcul-
ty breathing or swallowing. If you have any symptoms
of a serious allergic reaction, stop taking TRADJENTA
and call your doctor right away.
What should I tell my doctor before taking TRADJEN-
TA?
Tell your doctor about all the medicines you take, in-
cluding prescription and non-prescription medicines, vi-
tamins, and herbal supplements.
Tell your doctor if you take other medicines that can
lower your blood sugar, such as a sulfonylurea or in-
sulin. If you take TRADJENTA with another medicine
that can cause low blood sugar (hypoglycemia), such as
a sulfonylurea or insulin, your risk of getting low blood
sugar is higher. The dose of your sulfonylurea medi-
cine or insulin may need to be lowered while you take
TRADJENTA. Signs and symptoms of low blood sugar
may include headache, drowsiness, weakness, dizziness,
confusion, irritability, hunger, fast heart beat, sweating,
or feeling jittery.
Also tell your doctor if you take rifampin (Rifadin(R),
Rimactane(R), Rifater(R), Rifamate(R)), an antibiotic
that is used to treat tuberculosis.
TRADJENTA may affect the way other medicines work,
and other medicines may affect how TRADJENTA
works.
Tell your doctor if you are pregnant or planning to be-
come pregnant or are breastfeeding or plan to breastfeed.
What are the possible side effects of TRADJENTA?
The most common side effects of TRADJENTA include
stuffy or runny nose and sore throat.
You are encouraged to report negative side effects of
prescription drugs to the FDA. Visit www.fda.gov/med-
watch or call (800) FDA-1088.
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Job Opportunities Growing In The Criminal Justice Field
(ARA) - Careers in criminal justice are many and varied
and continued growth is expected in the feld. Growth
among careers in law enforcement and investigation is re-
ported at 22 percent, an above average gain, according to
the Bureau of Labor Statistics. The same published report
projects 9 percent growth among probation offcers and
corrections personnel. This projection represents an aver-
age growth rate, but growth just the same.
To give you an idea of the options available in this growing
industry, Audrey Pasin, an attorney and full-time faculty
member in the criminal justice program at Brown Mackie
College - Greenville offers her advice.
Our graduates with an associates or bachelors degree or
with a certifcate in the colleges criminal justice program
are equipped to pursue employment in diverse areas of the
criminal justice feld, Pasin says. Theyre exploring posi-
tions in both private and government sectors.
In the current economic climate, law enforcement posi-
tions in most big cities are tough to get. They tend to look
for people with a military background and prefer a can-
didate with a masters degree, says Pasin. Colleges like
Brown Mackie College - Greenville prepare students for
other options that require less time in school.
As a new class enters the Criminal Justice program, Pa-
sin asks students what they like to watch on TV to gauge
their desired career direction within the feld. The numer-
ous popular forensics dramas sometimes prompt students
to enroll with unrealistic expectations. We train students
for supporting roles in a forensics unit; however, it gen-
erally takes at least a bachelors degree to understand the
science required to become a crime scene analyst, says
Pasin. The majority of our students say they have come
to us for training so they can help people in trouble. Most
want to help kids.
A criminal justice degree or certifcate provides a founda-
tion in human service felds, such as social work. This feld
alone offers many different types of positions. Social work-
ers provide assistance to adults and children coping with
diffcult issues such as disabilities, inadequate housing,
unemployment, substance abuse and domestic conficts,
among many others. Students can pursue opportunities as
a probation offcer, case worker, or even working with a
school or hospital to support those in need.
Another avenue of employment opportunities lies in the
security industry. A multitude of businesses hire security
guards and surveillance offcers to guard people, mer-
chandise, money or equipment. Students can inquire about
these positions at museums, department stores, banks and
hospitals, to name a few. Training also provides entry lev-
el opportunities as a private investigator, Pasin says. In-
surance companies, attorneys and individuals hire people
to locate information on legal, fnancial or personal mat-
ters. The court system employs security personnel, bailiffs,
custodians of evidence and record-keeping. Another good
place to look is the corrections industry for a position as a
prison guard.
A career in one feld can transition into the other. As stu-
dents broaden the scope of the search for employment, they
now look into open positions at both the public defenders
and prosecutors offces. Its amazing how much of the
approach to criminal justice comes from understanding so-
ciety. Whos in the system, how the system works, Pasin
says.
Criminal justice training focuses on sociology and psy-
chology research. Students come away with a global un-
derstanding of how people operate and how a family func-
tions. Because of this social dynamic, the criminal justice
programs have applications in the family law and employ-
ment law felds. In this economy, I encourage students to
think broadly outside of traditional places, says Pasin.
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Page 11
Set The Scene For Easy Outdoor Entertaining
(ARA) - Its not hard to get people to come to an outdoor
gathering on a warm summers evening, and it should
be just as easy to pull together a memorable affair. To
make the most of your time and budget, look for low-
maintenance solutions that you can use throughout the
season - and in summers yet to come. From the dishes
you serve to the way you decorate, the less work you
have to do, the more youll be able to enjoy the time with
your guests.
Get your backyard ready for summer gatherings with
these easy tips:
* Decking - Having a great space where guests can gather
is the frst, and perhaps most essential, task. A deck gives
guests a place to relax and linger comfortably through-
out your party. If youre concerned about the time youll
have to put into keeping your deck looking great, toss out
your old ideas of decks requiring careful maintenance
and attention year-round. Opt for the low maintenance
decking materials now on the market and your deck will
be ready to welcome guests when you are. TimberTechs
Earthwood Evolutions line offers hardwood style deck
materials that resist scratching, staining and fading, mak-
ing them ideal for those who want the
look of wood without the extensive
care it requires.
* Plants - As much as you want your
deck and gathering space to look good,
you want guests to be impressed by
the natural surroundings of your yard
as well. Research perennial plants that
thrive not just in your horticultural
zone, but in the microclimate of your
home (your particular soil type, sun
exposure, etc.) Choose hardy plants
that dont require too much prun-
ing or attention, but which provide a
beautiful and varied backdrop. If you
dont have a green thumb, talk to the
experts at a local garden center to get
tips on plant selection and care.
* Decor - From serving ware to seating,
you can assemble all the elements of entertaining with-
out too much stress. If you want to freshen up the look of
your deck, invest in weather-resistant outdoor furniture
that can stand up to the elements and will look good in
years to come. If new furniture isnt in your budget, look
for new cushions and covers that will resist spills and
tears. Instead of buying disposable serving ware, look
for shatter-proof plates and glasses that are dishwasher
safe. Youll be doing the environment a favor and youll
always have it on hand - no more last-minute runs to the
store when you run out of plastic cups.
* Food - Dont stress yourself out with a multi-course
menu. Since its summer, let seasonal ingredients be the
stars. Serve sliced or grilled fresh fruit for a sweet des-
sert and rely on tried-and-true party favorites, but with
a different spin. Instead of Buffalo wings, try Zesty
Cheater Wings that are about as easy - and delicious - as
it gets. Serve them with a fresh tossed salad and youve
got summer on a plate.
Zesty Cheater Wings
Recipe by Kent Whitaker, provided by TimberTech
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This recipe is so easy its almost like cheating. Put a
twist on chicken marinated in Italian dressing with a few
quick and easy ingredient additions.
Ingredients:
12 to 24 mini wings and drums
Zesty Italian dressing
Barbecue sauce
Minced green pepper
Minced onion
Parsley fakes
Directions:
Marinate the chicken in equal parts of Italian dressing
and barbecue sauce. Toss in some hot sauce and spoon in
a few tablespoons of minced peppers, onions and some
dried parsley fakes. Cover, chill for a couple of hours
and grill until juices run clear.
Page 13
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The Changing Landscape Of Cancer Treatments
(ARA) - In his recent bestseller, The
Emperor of All Maladies: A Biogra-
phy of Cancer, cancer physician
and researcher Siddhartha Mukher-
jee writes that a decade from now,
its likely most Americans will know
at least one person with chronic my-
eloid leukemia (CML).
Theres no epidemic here, CML is
still a rare disease. The same num-
bers of people are being diagnosed
with this form of blood cancer, or
leukemia, each year. Its just that
more and more people with CML are
living out their lives. This is due to a
fundamental change in how this can-
cer is treated.
The research leading to the new gen-
eration of medicines for CML spans
decades, with hundreds of scientists
around the world devoting their ca-
reers to understanding this mysterious disease. A key ad-
vance was made in the 1970s, with the discovery of possibly
the frst human oncogene (cancer-causing gene), Bcr-Abl.
A fip-fop of two pieces of genetic material, Bcr-Abl sets
off the cascade of signals that tells the body to produce the
cancerous white blood cells that mark this form of leuke-
mia.
The following years saw more research on the role of Bcr-
Abl in CML and the simultaneous development of a new
class of drugs that act differently from conventional che-
motherapy. These drugs were not cytotoxic (cell-killing);
instead, they specifcally blocked the ability of the Bcr-Abl
gene to send the signals that drive abnormal blood cells to
divide and block out normal, healthy blood cells.
A retired train conductor read a story in his local newspaper
about one of these new drugs, called Bcr-Abl inhibitors,
under study at the University of Oregon. He had been diag-
nosed with CML. He knew it was a very bad disease, with
a median survival of three to six years, and with limited
treatment options.
He bravely volunteered to be the frst person to try the treat-
ment. He survived, followed by a few other volunteers in
the frst clinical study, then hundreds more in large clinical
trials and thousands more in clinical practice.
Advances in research continue on Bcr-Abl, yielding ever-
improving outcomes for CML patients treated with Bcr-Abl
inhibitors. These new treatments have shown that therapies,
developed based on a study of the biology of cancer cells,
can improve control of the disease and work with fewer
side effects. They also provide inspiration for research and
understanding of the core makeup of other cancers in the
effort to match the success seen with these CML treatments.
Learn more about Bcr-Abl inhibitors and other areas of can-
cer research by visiting the National Cancer Institute web-
site (www.cancer.gov) and ClinicalTrials.gov. In addition,
CML Earth (www.cmlearth.com) is a global, interactive
social network for CML patients, caregivers, and patient
groups, sponsored by Novartis Oncology, and dedicated to
connecting the CML community from around the world.
Researchers work to fnd the new generation of medicine to treat chronic
myeloid leukemia (CML).
Page 16
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ATVs & Scooters made on a Yamaha Installment Financing loan account from 12/29/10-6/30/11. Minimum contract length is 24 months and maximum length is 36 months. Minimum
amount fnanced is $5,000. Fixed APR of 3.99%or 12.99%will be assigned based on credit approval criteria. Monthly payments per $1,000 fnanced based on 36 month termare $29.52 at
3.99%and $33.69 at 12.99%. Offer good only in the U.S., excluding the state of Hawaii. Dress properly for your ride with a helmet, eye protection, gloves and boots. Do not drink and ride.
It is illegal and dangerous. Yamaha and the Motorcycle Safety Foundation encourage you to ride safely and respect the environment. For further information regarding the MSF course, please
call 1-800-446-9227. ATVs with engine sizes over 90cc are recommended for use only by riders age 16 years and older. Yamaha recommends that all ATV riders take an approved training
course. For safety and training information, see your dealer or call the ATV Safety Institute at 1-800-887- 2887. ATVs can be hazardous to operate. For your safety: Always avoid paved surfaces.
Never ride on public roads. Always wear a helmet, eye protection and protective clothing; never carry passengers; never engage in stunt riding; riding and alcohol/drugs dont mix; avoid
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