Professional Documents
Culture Documents
An introduction to immunology
Aim: A very general introduction to immunology. Explain how molecular interactions are essential for the immune system. Why: Several articles in this seminar deals with interaction between molecules in the immune system. Some extra motivation why studies of biomolecular interactions are important.
B and T
Immunology
Immunology is the study of our protection from foreign macromolecules or invading organisms and our responses to them. Host e.g. me!!!! Foreign macromolecule, antigen e.g. virus protein, worm, parasite (Everything that should not be in my body)
B cells
Surface bound antibody Antibody secreting B cell Antigen B-cell
Virus killed
T cells
Two types:
Helper T cells (Th): activates other cells Cytotoxic T cells (Tc): can kill other cells
T cells can only recognize antigens associated with certain molecules (MHC)
Cancer
The second ranking cause of death after heart disease in the Western world. most organs and tissues in an organism are in balance (death and renewal) cancer cells have no control in growth mechanisms, can expand to a large size producing a tumor
ELISA
HIV HBV HCV HAV Toxoplasma TB and so,
Components of blood
Serum vs. Plasma Serum: cell-free liquid, minus the clotting factors Plasma: cell-free liquid with clotting factors in solution (must use an anticoagulant)
Composition of blood
The composition of blood is actually quite complex, it consists of aqueous plasma and formed elements (cells).
Blood
Plasma
Formed Elements
(corpuscles)
Blood Bank do many several test on blood unite to be ensure that the unite is safe to transfusion.
Platelets
RBC
Plasma
Sure Not
PrePre-Transfusion Test
Is to provide safe, compatible blood fot transfusion to each individual patients. The steps necessary for safe transfusion are
1. 2. 3.
4. 5.
Accurate ABO & Rh Typing of the patients and donor too. Screening tests for antibodies in donors and patients serum. In the presence of patient antinbodies, selection of appropriate unite for each patient. Compatibility Testing. Accurate Comletion of paperwork and labels.
Transfusion
After ensure of the unite and its compatability with patients. We sould be monitering patient during transfuion to be sure is no problem and there no any trasfusion reaction.