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Neuroepigenetics of Learning and Memory

Neuroepigenetics of Learning and Memory

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Published by Travis Chapman
Undergraduate thesis by Travis Chapman (Baylor University)
Undergraduate thesis by Travis Chapman (Baylor University)

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Categories:Types, Research
Published by: Travis Chapman on Jul 25, 2011
Copyright:Public Domain

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05/15/2013

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Epigenetics and Memory
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 Running head: EPIGENETICS AND MEMORY Neuroepigenetics of Learning and MemoryA Thesis Submitted to the Faculty of Baylor UniversityIn Partial Fulfillment of the Requirements for theHonors ProgramByTravis ChapmanWaco, TexasMay 2011
 
Epigenetics and Memory
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 AbstractLong-term memory formation requires changes in gene expression. One mechanism for altering gene expression involves chemical modifications of DNA or its associatedhistone molecules. These “epigenetic” tags have long been studied by developmental biologists for their role in cell differentiation, but recent evidence suggests they alsocoordinate behavior in terminally differentiated neurons. Epigenetic chemicalmodifications include DNA methylation as well as histone methylation, acetylation, phosphorylation, ubiquitylation, and sumoylation. DNA methylation and histonemodifications—in particular acetylation, methylation, and phosphorylation—play a keyrole in regulating memory-related behavior. Moreover, neuroscientists investigatingepigenetics have identified potential targets for therapeutic intervention in diseases likeAlzheimer’s, especially with regard to histone deacetylases (HDACs).
 
Epigenetics and Memory
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 Table of ContentsIntroduction ………………………………………………………………………...…….4What is epigenetics? ………………………………………………………………...........5Histone Acetylation ……………………………………………………..……….....…...12Histone Phosphorylation and Methylation ………………………………………...……26DNA Methylation .............................................................................................................31Challenges and Future Research ......................................................................................38References ........................................................................................................................41

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