Perioperative Management of Perioperative Management of Iron Deficiency AnemiaIron Deficiency AnemiaPerioperative Management of Perioperative Management of Iron Deficiency AnemiaIron Deficiency Anemia
Moises Auron MD FAAP, FACPMoises Auron MD FAAP, FACPHospital MedicineHospital Medicine
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egulation of Iron Metabolism
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egulation of Iron Metabolism
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egulation of Iron Metabolism
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egulation of Iron Metabolism
Normal body iron content ~ 3 to 4 g.Normal body iron content ~ 3 to 4 g.
--HemoglobinHemoglobin~ 2.5 g~ 2.5 g
--IronIron--containing proteins (eg, myoglobin,containing proteins (eg, myoglobin,
cytochromes, catalase) ~ 400 mgcytochromes, catalase) ~ 400 mg--TransferrinTransferrin--bound ~ 3 to 7 mgbound ~ 3 to 7 mg
--Storage iron (ferritin; hemosiderin)Storage iron (ferritin; hemosiderin)
Storage varies according to gender Storage varies according to gender
--Men ~ 1 g (liver, spleen, and bone marrow).Men ~ 1 g (liver, spleen, and bone marrow).
--WomenWomen ± ±depends on physiologic factorsdepends on physiologic factors
(menses, pregnancies, deliveries, lactation, and(menses, pregnancies, deliveries, lactation, andiron intake).iron intake).
Muñoz M. Vox Sanguinis. 2008; 94: 172±183
R
egulation of Iron Metabolism
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egulation of Iron Metabolism
R
egulation of Iron Metabolism
R
egulation of Iron Metabolism
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Preoperative Use of Parenteral Iron
This is a comprehensive review of the pathophysiology and physiology of iron deficiency anemia, as well as the evolution of the intravenous iron utilization to the current practice.
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