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Pharma 04

Pharma 04

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Published by hamza jassar

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Published by: hamza jassar on Sep 27, 2008
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06/16/2009

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ONIVERSIlY
Of
JORDAN
'?'
Faculty
OF
Medicine
,.
-----
o
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U
?-_</
\\
,
~ o ~
LECTURE
NO:
II
_
DONEBY:
ZAIJ.
D>
~ M J
I
. 1 I I ~ . t { A I J $ A I f '
 
Bythename
of
allah
**Type
of
receptors:Wehave4types
of
receptorsinevery
human
body.Receptor:kind
of
proteinamongthetargetandthedrug.
1.
ligand-gatedionchannel:
LigandmeansagonistInthiscasetheinteractionbetweenthedrugs(agonist)andreceptorcausesopening
of
ionchannel.e.g:
1.
Nicotinicreceptor2.AcetylcholinereceptorLocation:nervoussystemEffect:withinmilliseconds
2.G-proteincoupledreceptors
Initiateeffectsthroughactivation
of
guaninenucleotidebindingproteinGTP-7GDP
-7
Adenylatecyclase
-7
ATP-7cyclic
AMP
(2
nd
messenger)Kinases
-7
proteinphosphorylatione.g:
1.
muscarinicreceptors2.acetylcholinereceptors3.B-adrenoreceptorsLocation:cellmembraneEffect:withinsecondsB-adrenoreceptors:leadstoglycogenandfatmetabolisminliver,fatandmusclecells
3.Kinase-likereceptors
It
causes
-7
proteinphosphorylation
-7
Genestranscription
-7
proteinsynthesis
-7
cellulareffects1
 
So
itsactionbecomesclearafterfewhourse.g:insulin,growthfactors,cytokinesreceptors
4.Nuclearreceptors
Location:cytoplasmorinnucleusEffect:afterdayse.g:steroidreceptorsdrugsthat
don't
fitthedrug-receptormodal(drugsdon'tactthroughreceptors)thekind
of
drugsreactwiththeirtargetsuchas:
1.
osmoticdiruretic
2.
antacidswhichgivetopatientsufferingfromacidity,inthiscasetheinteractionbetweenacid(mainlyHCI)andalkaline(base)directlywithoutreceptors.ThebiologicalTargetscouldbe:
1.
Ionchannelinourbody(e.g:Na+channel)
2.
enzymesHumanbodyfull
of
enzymesthatreactwithcertaintype
of
drugs
3.
macromolecules(e.g:DNA,RNAandspecialproteins)TheinteractionbetweenthedrugandDNAcausemutationinthecell.4.cellmembranecarriers:Certaindrugs
can't
enterthecellwithoutinterationwithcarriers
in
cellmembrane.Pharmacokinetics:Theaction
of
humanbodyonthedrugs(unlikepharmacodynamics)

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