Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Download
Standard view
Full view
of .
Look up keyword
Like this
1Activity
0 of .
Results for:
No results containing your search query
P. 1
MNPsheet

MNPsheet

Ratings: (0)|Views: 5|Likes:
Published by Sayoni Das

More info:

Published by: Sayoni Das on Aug 24, 2011
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as DOC, PDF, TXT or read online from Scribd
See more
See less

08/24/2011

pdf

text

original

 
MAGNETIC NANOPARTICLES (MNPs)
SYNTHESIS, FUNCTIONALIZATION AND BIOMEDICAL APPLICATIONS
Magnetic nanoparticles are a class of engineered particulate materials that can bemanipulated under the influence of an external magnetic field.
 They are commonly composed of magnetic elements, such as Fe, Ni, Co and theiroxides like magnetite (Fe
3
O
4
), maghemite (٧-Fe
2
O
3
), cobalt ferrite (Fe
2
CoO
4
) etc.
 They have been the focus of much research recently because they possess theseproperties: small size (1-100nm) comparable to virus, proteins; large surface area;superparamagnetic; amenable to surface modification – solubility, biocompatibilitycan be manipulated.
Challenges in MNP research: 1) a good synthesis route for manufacturingmonodisperse MNPs2) a good method to functionalize the surface of thenanoparticles
Synthesis: 1) Precipitation from soln Coprecipitation, Microemulsions, Polyols, Thermal decomposition2) Aerosol/vapor methods – Spray Pyrolysis, Laser Pyrolysis3) Biomimetic – Magnetosome (magnetotactic bacteria), Ferritin
Functionalization of MNP is an effective approach to modify their surface properties. Two types –1)Biological functionalization – Attachment of biological entities like proteins,Ligands, antibodies etc.2)Chemical functionalization - Chemical functional groups and polymer chainslinked by bindings.
Considerations of a biomedical magnetic nanoparticle: toxicity, biocompatibility,uniformity in all respects of their size, magnetic and coating characteristics, easysynthesis and low cost.
Biomedical Applications of MNPs: Targeted Drug delivery, Hyperthermia, MRIcontrast agents, Transfection, Immunoassays, Biosensing, Magnetic relaxationswitching technology, Magnetic separation, remote control of cellular behavior usingnanomagnetic actuation etc.
Principle used in most MNP applications: Magnetic nanoparticle tagged cells ormolecules, provide the
ability to be directed and concentrated
within thetarget by means of external magnetic field and to be removed when desired.

You're Reading a Free Preview

Download
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->