Origin and ScopeOrigin and Scope
of of Antibiotics & AntimicrobialAntibiotics & AntimicrobialAgentsA
The discovery of Antimicrobial drugs haveThe discovery of Antimicrobial drugs havesuccessfully controlled the majority of bacterial,successfully controlled the majority of bacterial,parasitical, fungal infections during the last 70-year.parasitical, fungal infections during the last 70-year.
SulfonamideSulfonamide1934,1934,Penicillin GPenicillin G1941 (Penicillium1941 (Penicilliumnotatum).. Followed Aminoglycosides (notatum).. Followed Aminoglycosides (StreptomycinS
ycin,,1946, Soil Bacteria..Actinomyces)1946, Soil Bacteria..Actinomyces)
At present 100 antimicrobialAt present 100 antimicrobialdrugsdrugsof different classesof different classesare available for use in humans.are available for use in humans.
Clinically effective antimicrobial agents should exhibitClinically effective antimicrobial agents should exhibit
selective toxicityselective toxicit
toward the bacterium not thetoward the bacterium not thehosthost....FewFewSide EffectsSide Effects.. Good.. Goodpharmacokinetics