HypersensitivityPneumonitis
Extrinsic Allergic Alveolitis
Martha Burk MD, MS
 
 
Definition
“…a group of immunologically mediatedlungdiseases in which the repeated inhalation of certain finely dispersed antigens of a widevariety, mainly including organic particles or low molecular weight chemicals, provokes ahypersensitivity reaction withgranulomatousinflammation in the distal bronchioles andalveoliof susceptible subjects
Bourke et al Eur Respir J 2001
 
 
Epidemiology
First recognized in grain workers in 1713
Prevalence difficult to assess
Not caused by a single etiologic agent
A complex syndrome varying in
Intensity
Clinical presentation
Lack of agreement on diagnostic criteria

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