Case 2 - UTI
Ascending urinary tract infection
Reaches Pyelum of kidney
Dividing into: A) Acute Pyelonephritis B) Chronic Pyelonephritis
Acute pyelonephritis (APN)
More common in women than men
Women have a short urethra
Urinary Tract Obstructionii.
Medularry Sponge kidneyiii.
Sickle cell trait/disease
Vesicoureteral reflux (VUR) with ascending infection
Intravesical portion of the ureter is normallycompressed with micturition
Prevents reflux of urine into the uterus
In VUR, the intravesical portion of the ureter is notcompressed during micturition
Urine refluxes into the uretersii.
Most common mechanism for UTI in females
Distal urethra and vaginal introitus are normallycolonised by E. Coli
Oragnisms ascend into urethra and bladder
Causes urethritis and cystitis
If VUR is present, infected urine ascends to the renalpelvis and renal parenchyma