EEEB W2001 MIDTERM 1 FALL 20072
(2 pts) Fill in the following table using ONLY terms from the list below (please, no substitutions).
Note that some cells in the table require more than one term for a complete answer, and that some terms may be used more than once.
EXAMPLE TERM(S) FROM ABOVE(ENTER LETTERS)
The way two or more proteins are associated with one another to form a larger protein, such as the way four globular proteinscombine to form a hemoglobin molecule, refers to a protein’s
The following elements of protein structure are determined bythe amino acid sequence in a protein (i.e., alter the sequence,and this (these) elements of structure are likely to be altered)
The portion of a protein that binds to DNA, such as that coded by the homeobox, refers to a protein’s
Alternating between an
pleated sheet refers to a protein’s
The function of a regulatory protein is likely to be lost or altered if these elements of structure are changed:
A, B, C, D, E, F*we’re allowing partial credit for some answers such as C in the fourth part, thought “alternating”refers to motifs, not secondary structure, but helices and sheets are secondary structure.
(0.5 pt) The synthesis of a cell membrane protein, such as a cell surface receptor, would begin withgene transcription, follow through with gene translation, then transported through several organelles,and eventually inserted into the cell’s outer membrane. The sequence of organelles involved with this process would be (RER = rough endoplasmic reticulum and SER = smooth endoplasmic reticulum)a)
nucleus, ribosome, RER, SER, transport vesicle, Golgi apparatus, transport vesicle, cell membrane b)
nucleus, ribosome, SER, RER, transport vesicle, Golgi apparatus, transport vesicle, cell membranec)
nucleus, RER, SER, Golgi apparatus, ribosome, mitochondrion, lysosome, cell membraned)
nucleus, mitochondrion, ribosome, Golgi apparatus, SER, RER, vacuole, cell membranee)
nucleus, micronucleus, ribosome, transport vesicle, RER, SER, cell membrane8)
(2 pts) Place an x in the appropriate column for the following cell membrane protein functions. Notethat there can be more than one x in a column.
MEMBRANEPROTEINFUNCTIONHIV’sinfection of aCD4 cellinvolvesControl of osmoticpressure bychemically gated ionchannels involvesCadherin-mediated junctionsinvolveG-protein coupledreceptor activation of akinase pathwayinvolves
Transporter XEnzyme XCell surfacereceptor X X XCell-to-celladhesionXAttachments tocytoskeletonX4.50 pts