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Mycology Lec3cutaneous

Mycology Lec3cutaneous

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Published by: api-3700579 on Oct 14, 2008
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03/18/2014

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MICROBIOLOGY LECTURE M3 \u2013 Cutaneous Mycoses
Lecture and Notes by Evelina N. Lagamayo M.D.
USTMED \u201907 Sec C \u2013 AsM

CUTANEOUS MYCOSES
CHARACTERISTICS
\u2022
diseases of the skin, hair, and nails
\u2022
involves the keratinized layers of the skin and its
appendages
\u2022
clinical manifestation:tinea orringwor m
o
Ex. Tinea pedis, tinea ungium,tinea corporis
ETIOLOGY :Der matophytes
\u2022
Classification in anamorphic state:

1. Microsporum
2. Trichophyton
3. Epidermophyton

\u2022
Teleomorphic state of Microsporum and Trichophyton is
genusArthroder ma
ECOLOGY AND EPIDEMIOLOGY
\u2022
Classification according to ecological niche:
1.Geophilic dermatophytes- isolated from the soil
2.Zoophilic dermatophytes- associtation with
domestic and wild animals and birds
3.Anthropophilic dermatophytes- associated with
humans and their habitats
Asexual State of Selected Dermatophytes
Classification of Dermatophytes According to Ecological Niche
General Characteristics of Macroconidia and Microconidia of
Dermatophytes
PATHOGENESIS
\u2022
\u201ckeratophilic fungi\u201d \u2013 use keratin as a substrate
\u2022
keratinases
Schematic Diagram of Tissues Colonized by Dermatophytes
A. Stratum corneum; B. Ectothrix hair infection; C. Entothrix hair
infection; D. favic hair infection
LABORATORY DIAGNOSIS
\u2022
KOH: 10%, 20%
\u2022
Except: T. schoenleinii causingfavus:
o

infected hair have a waxy mass of hyphal elements(scutulum) surrounding the base of the hair follicle at the scalp line.

o
microscopic exam: degenerated hyphal
elements coursing throughout the hairshaft
\u2022
Fungal Culture : SDA w/ cylcoheximide, chloramphenicol
o
conidia:
\ue000
macroconidia
\u2013
large
and
multicellular
\ue000
microconidia - small and unicellular
o
spiral hyphae, chlamydospores, nodular
bodies, racquet hyphae and chandeliers
TREATMENT
1.Azoles \u2013 miconazole, clotrimazole, econazole (topical)
-
Mechanism of action:
o

interferes with cytochrome P-450- dependent enzyme system s at the the demethylation step from lanosterol to ergosterol

2.Griseofulvin
-
fungistatic, affects the microtubular system of
fungi
-
interferes with the mitotic spindle and cytoplasmic
microtubules
-
oral route
Fungal infection of the hair,
endothrix infection
Fungal infection of the hair,
ectothrix infection

KOH preparation of skin scrapings. Dermatophytes showing septate hyphae

intertwined

among epithelial cells.(Phase contrast- 500X)

KOH smear of skin scrapings. M. furfur showing spherical yeast cells (A) and short hyphal fragments(B)

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