\u2022 Mecanism intermediar de boala
\u2022 insoteste sau complica un numar mare de boli si sindroame
\u2022 cauze multiple\u2192 activarea coagularii plasmei
(coagulare + fibrinoliza secundara)
\u2022 in majoritatea cazurilor procesul este sistemic si depaseste prin intensitate
si/sau persistenta mecanismele normale de comtrol
\u2022 efectele biologice
\u2022 consum de factori de coagulare (I, II, V, VIII, XIII)
\u2022 consum al trombocitelor
\u2022 consum al unor inhibitori naturali ai coagularii (AT III, PC, PS)
\u2022 fragmentarea intravasculara a eritrocitelor (\u2192 hemoliza microangiopatica)
\u2022 activarea secundara a fibrinolizei\u2192 biodegradarea Ia, I, V, VIII, FDP
\ue000 INFECTII SEVERE / SEPSIS (BACTERII, VIRUSURI, PARAZITI)
\ue000 TRAUMA (POLITRAUMATISM, TRAUMATISM CEREBRAL, EMBOLIE GRASA)
\ue000 DISTRUCTIE DE ORGAN (PANCREATITA)
\ue000 MALIGNITATE
