Obligate intracellular parasites-
Replication depends primarily on synthetic processes of the host cellViral Replication Steps1.
Attachment of the virus to the host cell2.
Entry of the virus through the host cell membrane3.
Uncoating of viral nucleic acid4.
Synthesis of early regulatory proteins5.
Synthesis of RNA or DNA6.
Synthesis of late, structural proteins7.
Assembly (maturation) of viral particles8.
Release from the cellANTIVIRAL AGENTS-
Progress in antiviral chemotherapy began in the
early 1950’s, when the search for anticancer drugs
generated several new compounds capable of inhibiting viral DNA synthesis.-
First-generation antiviral agents: (poor specificity that rendered them too toxic for systemic use, buteffective when used topically for treatment of herpes keratitis)
To be EFFECTIVE, antiviral agents must:
block viral entry/exit from the host cell
be active inside host cell
To be IDEAL, antiviral agents must be:
selective (no damage to host cell)
reduce symptom w/o affecting immune response
NEED for agents vs. viruses
Vaccine not available
Multiple serotypes ( e.g. rhinoviruses)
Constantly changing (e.g. influenza, HIV)