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drugs and the liver

drugs and the liver

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Published by: api-3761895 on Oct 16, 2008
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03/18/2014

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Drugs and the liver
Drugs and the liver
Effect of the liver on
the drugs :-
\u2022The liver transforms lipophylic to

hydrophylic drugs to be excreted
\u2022The are two phases I and II
\u2022It occurs by cytochrome P450

enzyme system
Factors affecting
biotransformation of drugs;-
1-Inducers (barbiturates, rifampicin, phenytion,
phenylbutazone, griseofulvin, smoking ) and
inhibitors (allopurinol, chloramphenicol, INH,
cimitidine , ketoconazol, oral contraceptives ) of
CYP
2- Hepatic blood flow: - N.B:- hepatic clearance =

hepatic blood flow x extraction ratio
3- Malnutrition
4- Age :-
5- Sex :- more activity in males than females

6- liver diseases
7- genetic factors (idiosyncracy)

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