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hormônios tireoidianos modificado

hormônios tireoidianos modificado

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Published by api-3763569
Aula Tributino
Aula Tributino

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Published by: api-3763569 on Oct 16, 2008
Copyright:Attribution Non-commercial

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03/18/2014

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Horm\u00f4nios tireoidianos
1

Dist\u00farbios da tire\u00f3ide s\u00e3o os dist\u00farbios end\u00f3crinos mais
comuns
Acometem 4-5% da popula\u00e7\u00e3o

T3 \u00e9 o horm\u00f4nio tireoidiano mais ativo
T4 \u00e9 secretado em maior quantidade
S\u00edntese

Sintetizados por c\u00e9lulas epiteliais foliculars da tire\u00f3ide
Fol\u00edculos de 200-300 \u00b5m de di\u00e2metro
Luz do fol\u00edculo contendo col\u00f3ide
Col\u00f3ide composto de Tireoglobulina + horm\u00f4nios tireoidianos

2
Est\u00edmulos para a secre\u00e7\u00e3o leva a endocitose do material
do col\u00f3ide pelas c\u00e9lulas epiteliais
\u2022
Mecanismos de seq\u00fcestro do iodeto (bomba de iodo)
\u2022
Estimulada por TSH (horm\u00f4nio estimulador da tire\u00f3ide)
\u2022
Tireoglobulina formada por 70 a.a. tirosina
\u2022
Iodo absorvido oxidado a I0 ou I3
-pela enzima peroxidase
\u2022
Formas oxidadas de iodo se combinam com o amino\u00e1cido
tirosina por a\u00e7\u00e3o da enzima iodinase

\u2022 Formam-se monoiodotirosina (MIT) e diiodotirosina (DIT)
MIT + DIT
DIT + DIT

T3 (triiodotironina)
T4 (tetraiodotironina)
3

Pequenas por\u00e7\u00f5es do col\u00f3ide sofrem pinocitose
Ves\u00edculas se fundem com proteases lisossomais
T3 e T4 se difundem para a circula\u00e7\u00e3o
93% liberados na forma de T4
7% liberados na forma de T3

Transporte dos horm\u00f4nios tireoidianos

99% associados a prote\u00ednas plasm\u00e1ticas
Principal delas \u2013 globulina de liga\u00e7\u00e3o a tiroxina (TBG)
TBG \u2013 sintetizada pelo f\u00edgado
Liberados lentamente para os tecidos
Dentro das c\u00e9lulas interagem com prote\u00ednas intracelulares

Regula\u00e7\u00e3o da produ\u00e7\u00e3o de T3 e T4

Ocorre por mecanismos de feedback negativos
Eixo hipot\u00e1lamo-hip\u00f3fise-tire\u00f3ide
Aumento das concnetra\u00e7\u00f5es de T3 e T4 no sangue inibem a

libera\u00e7\u00e3o de TSH pela adenohip\u00f3fise

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