Packaging in well designed blister packs using materials of low moisturetransmission drug can be protected from moisture.
Capsule, especially liquid filled sift gel capsules are proved to be beneficialbecause they are less subject to oxidative or hydrolytic degradation.
According to Banker (2002) and according to Aulton (2002) )
During capsule formulation some problems arises which create harmful effect onproduct. There are the following problems that can be considered as formulationchallenges of capsule formulation
Powder flow ability problem:
the final mixture of capsule may not have goodpowder flow ability which do not ensure delivery of sufficient powder to thecapsule during filling operation and thus affect uniform dosing.Sometimes there is remixing during powder handling in the filling equipmentitself.
there may be physical incompatibilities between activeingredients and diluents or between active ingredients and/or diluents and thecapsule shell.
The Vulnerability Problem:
the vulnerability of capsule may caused by theingredients that are hygroscopic which damage capsule wall. The damage occursdue to easy melting or absorption of water or moisture.
capsules can be soft, even sticky due to the lower melting point of mixed material or compounds.
Damage of Shell:
capsule shell can be damaged by volatile oils such as creosoteand alcohol.
Solution of the Challenges
Solution of Flow Ability:
the following ingredients may be considered for theimprovement of flow ability