Inhibits the enzyme responsible for the conversion of purines to uric acid, thus reducing the production of uric acid with a decrease in serum and sometimes in urinary uric acid levels, relieving the signs and symptoms of gout
Secondary hyperuricemia associated with various malignancies:
6\u201310 yr: 300 mg/day PO.
< 6 yr: 150 mg/day; adjust dosage after 48 hr of treatment based on serum uric
For geriatric patient or patients with creatinine clearance 10\u201320 mL/min, 200 mg/day; for
creatinine clearance < 10 mL/min, 100 mg/day; for creatinine clearance < 3 mL/min,
intervals between doses will need to be extended, based on patient's serum uric acid
CNS: Headache, drowsiness, peripheral neuropathy, neuritis, paresthesias
Dermatologic: Rashes\u2014maculopapular, scaly or exfoliative\u2014sometimes fatal
GI: Nausea, vomiting, diarrhea, abdominal pain, gastritis, hepatomegaly,
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