Beta1-selective adrenergic blocking agent
Blocks beta-adrenergic receptors of the sympathetic nervous system in the heart and
juxtaglomerular apparatus (kidney), thus decreasing the excitability of the heart,
decreasing cardiac output and oxygen consumption, decreasing the release of renin from
the kidney, and lowering blood pressure.
Use cautiously with renal failure, diabetes or thyrotoxicosis (atenolol can mask
the usual cardiac signs of hypoglycemia and thyrotoxicosis), lactation, respiratory
follow with IV injection of 5 mg 10 min later. Switch to 50 mg PO 10 min after
the last IV dose; follow with 50 mg PO 12 hr later. Thereafter, administer 100 mg
PO daily or 50 mg PO bid for 6\u20139 days or until discharge from the hospital.
Metabolism: T1/2: 6\u20137 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine (40%\u201350%) and bile and feces (50%\u201360%)
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