0.017 mg/mL; may also be infused undiluted; diluted solution is stable for 24 hr at room
temperature or for 48 hr refrigerated.
Infusion: Infuse slowly over 10 min.
Compatibilities: Compatible with 5% dextrose injection, 0.9% sodium chloride
Incompatibilities: Do not mix in solution with any other drugs.
CNS: Headache, light-headedness, dizziness, tingling in arms, numbness
CV: Ventricular arrhythmias, hypotension, hypertension
Increased risk of serious to life-threatening arrhythmias with disopyramide,
quinidine, procainamide, amiodarone, sotalol; do not give together
Increased risk of proarrhythmias with phenothiazines, TCAs, antihistamines
Use cautiously with digoxin because ibutilide may mask digoxin cardiotoxicity
History: Hypersensitivity to ibutilide; second- or third-degree AV heart block,
time of onset of atrial arrhythmia; prolonged QTc intervals; pregnancy, lactation;
Physical: Orientation; BP, P, auscultation, ECG; R, adventitious sounds
Determine time of onset of arrhythmia and potential benefit before beginning
therapy. Conversion is more likely in patients with arrhythmias of short (< 90
Ensure that patient is adequately anticoagulated, generally for at least 2 wk, if
atrial fibrillation lasts > 2\u20133 days.
Monitor ECG continually during and for at least 4 hr after administration. Be alert
for possible arrhythmias, including PVCs, sinus tachycardia, sinus bradycardia,
varying degrees of block at time of conversion.
Keep emergency equipment readily available during and for at least 4 hr after
Provide appointments for continued follow-up, including ECG monitoring;
tendency to revert to atrial arrhythmia after conversion increases with length of
time patient was in abnormal rhythm.
This drug can only be given by IV infusion. You will need ECG monitoring
during and for 4 hours after administration.