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Heparin inactivates factor XA, therefore inhibiting thrombus and clot formation by
blocking the conversion of prothrombin to thrombin and fibrinogen to fibrin, the final
steps in the clotting process. Heparin also inhibits the activation of factor XIII, thrombin-
induced activation of factors V and VIII.
Unlabeled uses: Adjunct in therapy of coronary occlusion with acute MI,
prevention of left ventricular thrombi and CVA post-MI, prevention of cerebral
thrombosis in the evolving stroke
Contraindicated with hypersensitivity to heparin; severe thrombocytopenia;
uncontrolled bleeding; any patient who cannot be monitored regularly with blood
coagulation tests; labor and immediate postpartum period; women older than 60
yr are at high risk for hemorrhaging.
Adjust dosage according to coagulation tests. Dosage is adequate when WBCT = 2.5\u20133
times control\u2014or APTT = 1.5\u20133 times control value. The following are guidelines to
Metabolism: T1/2: 30\u2013180 min
Distribution: Does not cross placenta, does not enter breast milk; broken down in liver
specifically ordered; direct incompatibilities in solution and at Y-site seen with amikacin,
codeine, chlorpromazine, cytarabine, diazepam, dobutamine, doxorubicin, droperidol,
ergotamine, erythromycin, gentamicin, haloperidol, hydrocortisone, kanamycin,
levorphanol, meperidine, methadone, methicillin, methotrimeprazine, morphine,
Adjust dose according to coagulation test results performed just before injection
(30 min before each intermittent dose or q 4\u20136 hr if continuous IV dose).
Therapeutic range APTT: 1.5\u20132.5 times control.
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