Inhibits the movement of calcium ions across the membranes of cardiac and arterial
muscle cells; inhibition of transmembrane calcium flow results in the depression of
impulse formation in specialized cardiac pacemaker cells, in slowing of the velocity of
conduction of the cardiac impulse, in the depression of myocardial contractility, and in
the dilation of coronary arteries and arterioles and peripheral arterioles; these effects lead
to decreased cardiac work, decreased cardiac energy consumption, and increased delivery
of oxygen to myocardial cells.
Initial dose, 10 mg tid PO. Maintenance range, 10\u201320 mg tid. Higher doses (20\u201330 mg tid\u2013qid) may be required, depending on patient response. Adjust over 7\u201314 days. More than 180 mg/day is not recommended.
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