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Nifedipine

Nifedipine

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Published by api-3797941

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Published by: api-3797941 on Oct 17, 2008
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05/09/2014

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nifedipine
(nyefe d' i peen)
Adalat, Adalat CC, Adalat XL (CAN), Apo-Nifed (CAN), Gen-Nifedipine
(CAN), Nifedical XL, Novo-Nifedin (CAN), Procardia, Procardia XL
Pregnancy Category C
Drug classes

Calcium channel-blocker
Antianginal
Antihypertensive

Therapeutic actions

Inhibits the movement of calcium ions across the membranes of cardiac and arterial
muscle cells; inhibition of transmembrane calcium flow results in the depression of
impulse formation in specialized cardiac pacemaker cells, in slowing of the velocity of
conduction of the cardiac impulse, in the depression of myocardial contractility, and in
the dilation of coronary arteries and arterioles and peripheral arterioles; these effects lead
to decreased cardiac work, decreased cardiac energy consumption, and increased delivery
of oxygen to myocardial cells.

Indications
\u2022
Angina pectoris due to coronary artery spasm (Prinzmetal's variant angina)
\u2022
Chronic stable angina (effort-associated angina)
\u2022
Sustained-release preparation only: Treatment of hypertension
\u2022
Orphan drug use: Treatment of interstitial cystitis
Contraindications and cautions
\u2022
Contraindicated with allergy to nifedipine.
\u2022
Use cautiously with lactation, pregnancy.
Available forms
ER tablets\u201430, 60, 90 mg; capsules\u201410, 20 mg
Dosages
ADULTS

Initial dose, 10 mg tid PO. Maintenance range, 10\u201320 mg tid. Higher doses (20\u201330 mg tid\u2013qid) may be required, depending on patient response. Adjust over 7\u201314 days. More than 180 mg/day is not recommended.

Sustained-release
30\u201360 mg PO once daily. Adjust over 7\u201314 days. Usual maximum dose is 90\u2013
120 mg/day.
Pharmacokinetics
Route
Onset
Peak
Oral
20 min
30 min
SR
20 min
2.5\u20136 hr

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