High Quality
Open the downloaded document, and select print from the file menu (PDF reader required).
tamsulosin hydrochloride
(tam soolow ' sin)
Flomax
Pregnancy Category B
Drug class
Alpha-adrenergic blocker (peripherally acting)
Therapeutic actions
Blocks the smooth muscle alpha1-adrenergic receptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck, leading to relaxation of the bladder and prostate and improving the flow of urine in cases of benign prostatic hypertrophy.
Indications
•
Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)
Contraindications and cautions
•
Contraindicated with hypersensitivity to tamsulosin, prostate cancer, pregnancy,
lactation.
•
Use cautiously with hypotension.
Available forms
Capsules—0.4 mg
Dosages
ADULTS
0.4 mg PO daily 30 min after the same meal each day; if response is not satisfactory in 2–
4 wk, dosage may be increased to 0.8 mg PO daily 30 min after the same meal each day.
PEDIATRIC PATIENTS
Safety and efficacy not established.
Pharmacokinetics
Route
Onset
Peak
Oral
Varies
4–6 hr
Metabolism: Hepatic; T1/2: 9–15 hr
Distribution: May cross placenta; enters breast milk
Excretion: Urine and feces
Adverse effects
•
CNS: Somnolence, insomnia
•
C V:Orthostatic hypotension,s ync ope
•
GI:Nausea,d yspepsia
•
GU:Abnormal ejaculation, decreased libido, increased urinary frequency
•
Other: Cough, sinusitis, rhinitis
Interactions
Add a Comment